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Literature summary for 2.7.7.50 extracted from

  • Sen, R.; Kaja, A.; Ferdoush, J.; Lahudkar, S.; Barman, P.; Bhaumik, S.R.
    An mRNA capping enzyme targets FACT to the active gene to enhance the engagement of RNA polymerase II into transcriptional elongation (2017), Mol. Cell. Biol., 37, e00029-17 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Saccharomyces cerevisiae YSB709
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the N-terminal of the enzyme promotes the recruitment of FACT (facilitates chromatin transcription that enhances the engagement of RNA polymerase II into transcriptional elongation) to the coding sequence of an active gene, ADH1, independently of mRNA capping activity. The absence of the N-terminal enzyme domain decreases FACT targeting to ADH1 and consequently reduces the engagement of RNA polymerase II in transcriptional elongation, leading to promoter-proximal accumulation of RNA polymerase II Saccharomyces cerevisiae ?
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additional information the N-terminal of the enzyme promotes the recruitment of FACT (facilitates chromatin transcription that enhances the engagement of RNA polymerase II into transcriptional elongation) to the coding sequence of an active gene, ADH1, independently of mRNA capping activity. The absence of the N-terminal enzyme domain decreases FACT targeting to ADH1 and consequently reduces the engagement of RNA polymerase II in transcriptional elongation, leading to promoter-proximal accumulation of RNA polymerase II Saccharomyces cerevisiae YSB709 ?
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Synonyms

Synonyms Comment Organism
CET1
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 Saccharomyces cerevisiae
mRNA capping enzyme
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 Saccharomyces cerevisiae