Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-fluoro-2'-deoxy-GTP | - |
Paramecium bursaria Chlorella virus 1 | |
2-amino-6-chloropurine-ribose triphosphate | - |
Paramecium bursaria Chlorella virus 1 | |
3'-deoxy-GTP | - |
Paramecium bursaria Chlorella virus 1 | |
3'-O-Methyl-GTP | - |
Paramecium bursaria Chlorella virus 1 | |
6-methylthio-GTP | - |
Paramecium bursaria Chlorella virus 1 | |
6-thio-GTP | - |
Paramecium bursaria Chlorella virus 1 | |
8-bromo-GTP | - |
Paramecium bursaria Chlorella virus 1 | |
8-iodoGTP | - |
Paramecium bursaria Chlorella virus 1 | |
GTP | - |
Paramecium bursaria Chlorella virus 1 | |
ITP | - |
Paramecium bursaria Chlorella virus 1 | |
N1-methyl-GTP | - |
Paramecium bursaria Chlorella virus 1 | |
O6-methyl-GTP | - |
Paramecium bursaria Chlorella virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Paramecium bursaria Chlorella virus 1 | Q84424 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2'-fluoro-2'-deoxy-GTP + pp(5')RNA | 0.16fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 2'-fluoro-2'-deoxy-G(5')ppp(5')RNA + diphosphate | - |
? | |
2-amino-6-chloropurine-beta-D-ribose triphosphate + pp(5')RNA | 0.08fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 2-amino-6-chloropurine-beta-D-ribose-(5')ppp(5')RNA + diphosphate | - |
? | |
3'-deoxy-GTP + pp(5')RNA | 0.15fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 3'-deoxy-G(5')ppp(5')RNA + diphosphate | - |
? | |
3'-O-methyl-GTP + pp(5')RNA | 0.38fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 3'-O-methyl-G(5')ppp(5')RNA + diphosphate | - |
? | |
6-methylthio-GTP + pp(5')RNA | 0.07fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 6-methylthio-G(5')ppp(5')RNA + diphosphate | - |
? | |
6-thio-GTP + pp(5')RNA | 0.16fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 6-thio-G(5')ppp(5')RNA + diphosphate | - |
? | |
8-bromo-GTP + pp(5')RNA | 0.40fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 8-bromo-G(5')ppp(5')RNA + diphosphate | - |
? | |
8-iodoGTP + pp(5')RNA | 1.0fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | 8-iodo-G(5')ppp(5')RNA + diphosphate | - |
? | |
GTP + pp(5')RNA | - |
Paramecium bursaria Chlorella virus 1 | G(5')ppp(5')RNA + diphosphate | - |
? | |
ITP + pp(5')RNA | 1.3fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | I(5')ppp(5')RNA + diphosphate | - |
? | |
additional information | generation of RNAs harboring various different cap analogues. Cap-dependent translation can occur in the absence of theN7-methyl group on the cap structure provided that alternative modifications enable appropriate binding to eIF4E | Paramecium bursaria Chlorella virus 1 | ? | - |
? | |
N1-methyl-GTP + pp(5')RNA | 1.1fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | N1-methyl-G(5')ppp(5')RNA + diphosphate | - |
? | |
O6-methyl-GTP + pp(5')RNA | 0.48fold efficiency compared with substrate GTP | Paramecium bursaria Chlorella virus 1 | O6-methyl-G(5')ppp(5')RNA + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
A103R | - |
Paramecium bursaria Chlorella virus 1 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.08 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | N1-methyl-GTP | |
0.1 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | GTP | |
0.15 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | O6-methyl-GTP | |
0.15 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 3'-deoxy-GTP | |
0.16 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 2-amino-6-chloropurine-ribose triphosphate | |
0.22 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 6-thio-GTP | |
0.34 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | ITP | |
0.42 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 8-iodoGTP | |
0.43 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 6-methylthio-GTP | |
0.45 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 3'-O-Methyl-GTP | |
1.4 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 2'-fluoro-2'-deoxy-GTP | |
1.5 | - |
IC50 value for formation of enzyme-GMP-complex, pH 7.5, 30°C | Paramecium bursaria Chlorella virus 1 | 8-bromo-GTP |