Literature summary for 2.7.7.50 extracted from

Picard-Jean, F.; Bougie, I.; Shuto, S.; Bisaillon, M.
The immunosuppressive agent mizoribine monophosphate is an inhibitor of the human RNA capping enzyme (2013), PLoS ONE, 8, e54621.

Search for more literature for 2.7.7.50

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
mizoribine 5'-phosphate	compound can inhibit the formation of the RNA cap structure catalyzed by human capping enzyme. In the presence of mizoribine 5'-phosphate, the RNA 5'-triphosphatase activity appears to be relatively unaffected while the RNA guanylyltransferase activity is inhibited. Mizoribine 5'-phosphate is a non-competitive inhibitor that likely targets an allosteric site	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
69000	-	x * 69000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60942	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant protein	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GTP + (5')ppPur-mRNA	-	Homo sapiens	diphosphate + G(5')pppPur-mRNA	-	?

Subunits

Subunits	Comment	Organism
?	x * 69000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
HCE	-	Homo sapiens

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Release 2023.1 (January 2023)