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Literature summary for 2.7.7.50 extracted from

  • Yamada-Okabe, T.; Mio, T.; Matsui, M.; Kashima, Y.; Arisawa, M.; Yamada-Okabe, H.
    Isolation and characterization of the Candida albicans gene for mRNA 5'-triphosphatase: association of mRNA 5'-triphosphatase and mRNA 5'-guanylyltransferase activities is essential for the function of mRNA 5'-capping enzyme in vivo (1998), FEBS Lett., 435, 49-54.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information expression of recombinant Candida albicans RNA 5'-triphosphatase GST-fusion protein in yeast RNA 5'-triphosphatase-deficient mutant cells binds to the guanylyltransferase of Saccharomyces cerevisiae and complements the growth defect of the mutant, while the human enzyme does not Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + pp(5')RNA Saccharomyces cerevisiae interaction of RNA 5'-triphosphatase and mRNA guanylyltransferase of the capping enzyme complex is essential for function and viability in vivo G(5')ppp(5')RNA + diphosphate guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue r
GTP + pp(5')RNA Saccharomyces cerevisiae yeast RNA 5'-triphosphatase enzyme can be substituted by the enzyme of Candida albicans, but not by the human enzyme, to function in the capping enzyme complex together with the mRNA guanylyltransferase G(5')ppp(5')RNA + diphosphate guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue r

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
 RNA 5'-triphosphatase-deficient mutant strain
-
Saccharomyces cerevisiae
-
 gene CEG1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + pp(5')RNA
-
 Saccharomyces cerevisiae G(5')ppp(5')RNA + diphosphate guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue ?
GTP + pp(5')RNA interaction of RNA 5'-triphosphatase and mRNA guanylyltransferase of the capping enzyme complex is essential for function and viability in vivo Saccharomyces cerevisiae G(5')ppp(5')RNA + diphosphate guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue r
GTP + pp(5')RNA yeast RNA 5'-triphosphatase enzyme can be substituted by the enzyme of Candida albicans, but not by the human enzyme, to function in the capping enzyme complex together with the mRNA guanylyltransferase Saccharomyces cerevisiae G(5')ppp(5')RNA + diphosphate guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue r

Subunits

Subunits Comment Organism
More subunit structure of capping enzyme Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
GTase
-
 Saccharomyces cerevisiae