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Literature summary for 2.7.7.49 extracted from

  • Akiyama, B.M.; Gomez, A.; Stone, M.D.
    A conserved motif in Tetrahymena thermophila telomerase reverse transcriptase is proximal to the RNA template and is essential for boundary definition (2013), J. Biol. Chem., 288, 22141-22149.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Tetrahymena thermophila

Protein Variants

Protein Variants Comment Organism
C232A mutation in CP2 motif, modest defect in RNA binding Tetrahymena thermophila
F230A mutation in CP2 motif, no effect on RNA binding Tetrahymena thermophila
H234A mutation in CP2 motif, modest defect in RNA binding Tetrahymena thermophila
I229A mutation in CP2 motif, modest defect in RNA binding Tetrahymena thermophila
R226A mutation in CP2 motif, strong defect in RNA binding Tetrahymena thermophila
R237A mutation in CP2 motif, strong defect in RNA binding Tetrahymena thermophila
Y231A mutation in CP2 motif, no effect on RNA binding Tetrahymena thermophila

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 gel filtration Tetrahymena thermophila

Organism

Organism UniProt Comment Textmining
Tetrahymena thermophila O77448
-
-

Subunits

Subunits Comment Organism
monomer 1 * 40000, SDS-PAGE Tetrahymena thermophila

General Information

General Information Comment Organism
physiological function the CP2 motif is in close proximity to a conserved region known as the template boundary element and acts as a RNA binding determinant. The CP2 motif binds the template boundary element to strictly define which telomerase RNA nucleotides can be reverse transcribed Tetrahymena thermophila