Cloned (Comment) | Organism |
---|---|
- |
Human immunodeficiency virus type 1 BH10 |
Crystallization (Comment) | Organism |
---|---|
crystal structure of inhibitor 6-([4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl]amino)-5,7-dimethylnaphthalene-2-carbonitrile bound to the active site of an isolated RNase H domain of HIV-1 reverse transcriptase at a resolution limit of 1.71 A | Human immunodeficiency virus type 1 BH10 |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7,8-dihydroxy-2H-chromen-2-one | - |
Human immunodeficiency virus type 1 BH10 | |
6-([4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl]amino)-5,7-dimethylnaphthalene-2-carbonitrile | i.e. F3284-8495, a specific inhibitor of reverse transcriptase RNase H, with low micromolar potency in vitro | Human immunodeficiency virus type 1 BH10 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus type 1 BH10 | P03366 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0004 | - |
RNase H activity, presence of 10 mM Mg2+, pH 8.0, temperature not specified in the publication | Human immunodeficiency virus type 1 BH10 | 4-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7,8-dihydroxy-2H-chromen-2-one | |
0.0008 | - |
RNase H activity, presence of 1 mM Mg2+, pH 7.4, temperature not specified in the publication | Human immunodeficiency virus type 1 BH10 | 4-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-7,8-dihydroxy-2H-chromen-2-one | |
0.0011 | - |
RNase H activity, presence of 10 mM Mg2+, pH 8.0, temperature not specified in the publication | Human immunodeficiency virus type 1 BH10 | 6-([4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl]amino)-5,7-dimethylnaphthalene-2-carbonitrile | |
0.0048 | - |
RNase H activity, presence of 1 mM Mg2+, pH 7.4, temperature not specified in the publication | Human immunodeficiency virus type 1 BH10 | 6-([4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl]amino)-5,7-dimethylnaphthalene-2-carbonitrile |