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Literature summary for 2.7.7.49 extracted from
- HIV-1 reverse transcription initiation: a potential target for novel antivirals? (2008), Virus Res., 134, 4-18.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 51000 | - |
1 * 66000 + 1 * 51000, the p66 subunit is composed of a DNA polymerase domain and an RNase H domain, whereas the p51 subunit contains only the polymerase domain | Human immunodeficiency virus 1 |
| 66000 | - |
1 * 66000 + 1 * 51000, the p66 subunit is composed of a DNA polymerase domain and an RNase H domain, whereas the p51 subunit contains only the polymerase domain | Human immunodeficiency virus 1 |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Human immunodeficiency virus 1 | uses the cellular tRNALys,3 molecule as primer | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | - |
Human immunodeficiency virus 1 | diphosphate + DNAn+1 | - |
? | |
| additional information | uses the cellular tRNALys,3 molecule as primer | Human immunodeficiency virus 1 | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 66000 + 1 * 51000, the p66 subunit is composed of a DNA polymerase domain and an RNase H domain, whereas the p51 subunit contains only the polymerase domain | Human immunodeficiency virus 1 |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Gag-Pol | reverse transcriptase precursor | Human immunodeficiency virus 1 |
| reverse transcriptase | reverse transcriptase is synthesized as part of the Gag-Pol precursor protein, which is cleaved by the virally encoded protease into the structural proteins and the replication enzymes reverse transcriptase, protease, and integrase | Human immunodeficiency virus 1 |
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