Literature summary for 2.7.7.49 extracted from

Biesinger, T.; Yu Kimata, M.T.; Kimata, J.T.
Changes in simian immunodeficiency virus reverse transcriptase alleles that appear during infection of macaques enhance infectivity and replication in CD4+ T cells (2008), Virology, 370, 184-193.

Search for more literature for 2.7.7.49

Protein Variants

Protein Variants	Comment	Organism
F227L	mutant shows 2 to 3fold increase in infectivity	Simian immunodeficiency virus
G211S	mutant shows 2 to 3fold increase in infectivity	Simian immunodeficiency virus
I148V	mutant shows 2 to 3fold increase in infectivity	Simian immunodeficiency virus
I257M	mutant shows 2 to 3fold increase in infectivity	Simian immunodeficiency virus
K412E	mutant demonstrates a 12fold increase in infectivity compared to the parental virus SIVmneCl8 indicating a role for mutations in the connection domain of reverse transcriptase in influencing viral infectivity and replication	Simian immunodeficiency virus
R173K	mutant shows 2 to 3fold increase in infectivity	Simian immunodeficiency virus
T288A	mutant shows 2 to 3fold increase in infectivity	Simian immunodeficiency virus
V108I	mutant shows 2 to 3fold increase in infectivity	Simian immunodeficiency virus

Organism

Organism	UniProt	Comment	Textmining
Simian immunodeficiency virus	-	-	-
Simian immunodeficiency virus mneCl8	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Simian immunodeficiency virus	diphosphate + DNAn+1	-	?
deoxynucleoside triphosphate + DNAn	-	Simian immunodeficiency virus mneCl8	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
reverse transcriptase	-	Simian immunodeficiency virus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)