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Literature summary for 2.7.7.49 extracted from

  • Abbondanzieri, E.A.; Bokinsky, G.; Rausch, J.W.; Zhang, J.X.; Le Grice, S.F.; Zhuang, X.
    Dynamic binding orientations direct activity of HIV reverse transcriptase (2008), Nature, 453, 184-189.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Human Immunodeficiency Virus reverse transcriptase supports RNA-directed DNA synthesis, DNA-directed DNA synthesis and DNA-directed RNA hydrolysis, the enzyme adopts opposite binding orientations on duplexes containing DNA or RNA primers, directing DNA synthesis or RNA hydrolysis activity respectively, binding orientation determines enzymatic activity of reverse transcriptase ?
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?

Organism

Organism UniProt Comment Textmining
Human Immunodeficiency Virus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
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Human Immunodeficiency Virus diphosphate + DNAn+1
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?
additional information reverse transcriptase supports RNA-directed DNA synthesis, DNA-directed DNA synthesis and DNA-directed RNA hydrolysis, the enzyme adopts opposite binding orientations on duplexes containing DNA or RNA primers, directing DNA synthesis or RNA hydrolysis activity respectively, binding orientation determines enzymatic activity of reverse transcriptase Human Immunodeficiency Virus ?
-
?

Subunits

Subunits Comment Organism
heterodimer heterodimer consisting of a p51 and a p66 subunit, the latter of which contains catalytically active DNA polymerase and RNAseH domains Human Immunodeficiency Virus

Synonyms

Synonyms Comment Organism
reverse transcriptase
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Human Immunodeficiency Virus