Literature summary for 2.7.7.49 extracted from

Lin, X.; Ma, Z.M.; Yao, X.; He, L.F.; Yuan, Z.H.; Ding, J.P.; Wen, Y.M.
Substitution of proline 306 in the reverse transcriptase domain of hepatitis B virus regulates replication (2005), J. Gen. Virol., 86, 85-90.

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Protein Variants

Protein Variants	Comment	Organism
P306A	replication competency is reduced to 12.75% of the wild-type value	Hepatitis B virus
P306D	replication competency is increased to 121.57% of the wild-type value	Hepatitis B virus
P306E	replication competency is increased to 940.59% of the wild-type value	Hepatitis B virus
P306F	replication competency is reduced to 41.18% of the wild-type value	Hepatitis B virus
P306G	replication competency is reduced to 1.96% of the wild-type value	Hepatitis B virus
P306L	replication competency is increased to 128.04% of the wild-type value	Hepatitis B virus
P306R	replication competency is reduced to 20.26% of the wild-type value	Hepatitis B virus
P306S	replication competency is reduced to 47.25% of the wild-type value	Hepatitis B virus
P306T	replication competency is reduced to 4.5% of the wild-type value	Hepatitis B virus
P306V	replication competency is increased to 152.75% of the wild-type value	Hepatitis B virus
P306Y	replication competency is reduced to 10.98% of the wild-type value	Hepatitis B virus

Organism

Organism	UniProt	Comment	Textmining
Hepatitis B virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Hepatitis B virus	diphosphate + DNAn+1	-	?

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Release 2023.1 (January 2023)