Literature summary for 2.7.7.49 extracted from

Deval, J.; Navarro, J.M.; Selmi, B.; Courcambeck, J.; Boretto, J.; Halfon, P.; Garrido-Urbani, S.; Sire, J.; Canard, B.
A loss of viral replicative capacity correlates with altered DNA polymerization kinetics by the human immunodeficiency virus reverse transcriptase bearing the K65R and L74V dideoxynucleoside resistance substitutions (2004), J. Biol. Chem., 279, 25489-25496.

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Protein Variants

Protein Variants	Comment	Organism
K65R	exhibits an 8-fold resistance to ddATP. 22fold decrease of the catalytic rate constant	Human immunodeficiency virus 1
K65R/L74V	84fold decrease of the catalytic rate constant. Virus replication capacity is severely impaired relative to wild-type enzyme. Poor ability of K65R/L74V RT to use natural nucleotides relative to wild-type enzyme: 15% that of wild-type enzyme for dATP, 36% for dGTP, 50% for dTTP, and 25% for dCTP	Human immunodeficiency virus 1

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 1	-	-	-

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Release 2023.1 (January 2023)