Literature summary for 2.7.7.48 extracted from

Musiu, S.; Castillo, Y.P.; Muigg, A.; Puerstinger, G.; Leyssen, P.; Froeyen, M.; Neyts, J.; Paeshuyse, J.
Quinolinecarboxamides inhibit the replication of the bovine viral diarrhea virus by targeting a hot spot for the inhibition of pestivirus replication in the RNA-dependent RNA polymerase (2020), Molecules, 25, 1283 .

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Protein Variants

Protein Variants	Comment	Organism
F224P	2-phenyl-N-(1-phenyl-1H-pyrazol-3-yl)-4-quinolinecarboxamide (CSFCII) resistant bovine viral diarrhea virus variants carry the F224P mutation in the viral RNA-dependent RNA polymerase (RdRp)	Bovine viral diarrhea virus 1
F224Y/N264D	2-(2-furanyl)-N-(6-methyl-2-benzothiazolyl)-4-quinolinecarboxamide (CSFCI) resistant bovine viral diarrhea virus variants carry two mutations in the viral RNA-dependent RNA polymerase (RdRp), N264D and F224Y	Bovine viral diarrhea virus 1

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	the CSFC analogues 2-(2-furanyl)-N-(6-methyl-2-benzothiazolyl)-4-quinolinecarboxamide and 2-phenyl-N-(1-phenyl-1H-pyrazol-3-yl)-4-quinolinecarboxamide do not inhibit the in vitro activity of recombinant Bovine viral diarrhea virus RNA-dependent RNA polymerase but inhibit the activity of Bovine viral diarrhea virus replication complexes	Bovine viral diarrhea virus 1

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nucleoside triphosphate + RNAn	Bovine viral diarrhea virus 1	-	diphosphate + RNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Bovine viral diarrhea virus 1	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Bovine viral diarrhea virus 1	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
RDRP	-	Bovine viral diarrhea virus 1
RNA-dependent RNA polymerase	-	Bovine viral diarrhea virus 1

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Release 2023.1 (January 2023)