Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.48 extracted from

  • Tchesnokov, E.P.; Feng, J.Y.; Porter,D.P.; Götte, D.
    Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir (2019), Viruses, 11, 326 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
remdesivir triphosphate the inhibitor causes a delayed chain termination at position i+5 Human respiratory syncytial virus A
remdesivir triphosphate the inhibitor causes a delayed chain termination at position i+5 Zaire ebolavirus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00017
-
 ATP pH 8, 30°C Human respiratory syncytial virus A
0.0005
-
 remdesivir triphosphate pH 8, 30°C Human respiratory syncytial virus A
0.0015
-
 ATP pH 8, 30°C Zaire ebolavirus
0.0057
-
 remdesivir triphosphate pH 8, 30°C Zaire ebolavirus

Organism

Organism UniProt Comment Textmining
Human respiratory syncytial virus A P28887
-
-
Human respiratory syncytial virus A A2 P28887
-
-
Zaire ebolavirus A0A068J9B1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RNAn
-
 Zaire ebolavirus diphosphate + RNAn+1
-
 ir
ATP + RNAn
-
 Human respiratory syncytial virus A diphosphate + RNAn+1
-
 ir
ATP + RNAn
-
 Human respiratory syncytial virus A A2 diphosphate + RNAn+1
-
 ir
remdesivir triphosphate + RNAn
-
 Zaire ebolavirus diphosphate + RNAn 3'-remdesivir
-
 ir
remdesivir triphosphate + RNAn
-
 Human respiratory syncytial virus A diphosphate + RNAn 3'-remdesivir
-
 ir
remdesivir triphosphate + RNAn
-
 Human respiratory syncytial virus A A2 diphosphate + RNAn 3'-remdesivir
-
 ir

Synonyms

Synonyms Comment Organism
RNA-directed RNA polymerase L
-
 Zaire ebolavirus
RNA-directed RNA polymerase L
-
 Human respiratory syncytial virus A