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Literature summary for 2.7.7.48 extracted from

  • Liu, Y.C.; Kuo, R.L.; Lin, J.Y.; Huang, P.N.; Huang, Y.; Liu, H.; Arnold, J.J.; Chen, S.J.; Wang, R.Y.; Cameron, C.E.; Shih, S.R.
    Cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with Prp8 (2014), PLoS Pathog., 10, e1004199.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of FLAG-tagged full-length enzyme in HEK-293 cells Enterovirus A71

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
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Enterovirus A71 5737
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nucleus enzyme 3Dpol and Prp8 are colocalized in the nucleus Enterovirus A71 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Enterovirus A71 cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with pre-mRNA processing factor 8, Prp8. Identification of potential protein targets of EV71 3Dpol by MALDI-TOF MS analysis, overview ?
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?
additional information Enterovirus A71 40 cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with pre-mRNA processing factor 8, Prp8. Identification of potential protein targets of EV71 3Dpol by MALDI-TOF MS analysis, overview ?
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?

Organism

Organism UniProt Comment Textmining
Enterovirus A71 Q2XTR4 a picornavirus, harvested from MOI-infected RD cells
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Enterovirus A71 40 Q2XTR4 a picornavirus, harvested from MOI-infected RD cells
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with pre-mRNA processing factor 8, Prp8. Identification of potential protein targets of EV71 3Dpol by MALDI-TOF MS analysis, overview Enterovirus A71 ?
-
?
additional information interaction of EV71 3Dpol and the nuclear protein U5 snRNPs. ENzyme 3Dpol enters the cellular nucleus and colocalizes with pre-mRNA processing factor 8, Prp8, 3Dpol associates with the C-terminal domain of Prp8 containing the Jab1/MPN region. RIP-seq of the pre-mRNA are trapped by the Prp8-3Dpol complexes Enterovirus A71 ?
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?
additional information cytoplasmic viral RNA-dependent RNA polymerase disrupts the intracellular splicing machinery by entering the nucleus and interfering with pre-mRNA processing factor 8, Prp8. Identification of potential protein targets of EV71 3Dpol by MALDI-TOF MS analysis, overview Enterovirus A71 40 ?
-
?
additional information interaction of EV71 3Dpol and the nuclear protein U5 snRNPs. ENzyme 3Dpol enters the cellular nucleus and colocalizes with pre-mRNA processing factor 8, Prp8, 3Dpol associates with the C-terminal domain of Prp8 containing the Jab1/MPN region. RIP-seq of the pre-mRNA are trapped by the Prp8-3Dpol complexes Enterovirus A71 40 ?
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?

Synonyms

Synonyms Comment Organism
3Dpol
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Enterovirus A71
picornaviral 3D polymerase
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Enterovirus A71
RDRP
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Enterovirus A71

General Information

General Information Comment Organism
physiological function mechanism of viruses attacking hosts whereby picornaviral 3D polymerase (3Dpol) enters the nucleus and targets the central pre-mRNA processing factor 8 (Prp8) to block premRNA splicing and mRNA synthesis. The 3Dpol inhibits the second catalytic step of the splicing process, resulting in the accumulation of the lariat-form and the reduction of the mRNA. 3Dpol inhibits intracellular pre-mRNA splicing by interacting with Prp8, modelling, overview Enterovirus A71