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Literature summary for 2.7.7.48 extracted from

  • Hodge, K.; Tunghirun, C.; Kamkaew, M.; Limjindaporn, T.; Yenchitsomanus, P.T.; Chimnaronk, S.
    Identification of a conserved RNA-dependent RNA polymerase (RdRp)-RNA interface required for flaviviral replication (2016), J. Biol. Chem., 291, 17437-17449.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Organism

Organism UniProt Comment Textmining
Dengue virus
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 a flavivirus
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Synonyms

Synonyms Comment Organism
RDRP
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 Dengue virus
RNA-dependent RNA polymerase
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 Dengue virus

General Information

General Information Comment Organism
physiological function probing of the entire Dengue genome for interactions via Y3H with viral RNA-dependent RNA polymerase reveals a dominant interaction as a loop-forming ACAG motif in the 3' positive-stranded terminus, RdRp recognizes the top loop of 3'-SL in both genomic forms, interactions sites coincides with known flaviviral recombination sites inside the viral protein-coding region. Specific recognition of the RNA element occurs via an arginine patch in the C-terminal thumb domain of enzyme RdRp. Disruption of the interaction results in loss of viral replication ability in cells. This unique RdRp-RNA interface is found throughout flaviviruses Dengue virus