Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-([5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
2-([5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
2-([5-(2-chloro-6-fluorophenyl)-1,3,4-thiadiazol-2-yl]-imino)-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
2-([5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
2-([5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
2-([5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
2-([5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]imino)-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(2,6-dichlorobenzylidene)-2-[[5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(2,6-dichlorobenzylidene)-2-[[5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(2,6-dichlorobenzylidene)-2-[[5-(2-chloro-6-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(2,6-dichlorobenzylidene)-2-[[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(2,6-dichlorobenzylidene)-2-[[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(2,6-dichlorobenzylidene)-2-[[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(2,6-dichlorobenzylidene)-2-[[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(3-fluorobenzylidene)-2-[[5-(2,4-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(3-fluorobenzylidene)-2-[[5-(2,6-dichlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(3-fluorobenzylidene)-2-[[5-(2-chloro-6-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(3-fluorobenzylidene)-2-[[5-(2-chlorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(3-fluorobenzylidene)-2-[[5-(2-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(3-fluorobenzylidene)-2-[[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
5-(3-fluorobenzylidene)-2-[[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]imino]-1,3-thiazolidin-4-one | - |
Hepacivirus C | |
additional information | synthesis and evaluation of 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase, docking study and molecular modelling, overview | Hepacivirus C |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | required | Hepacivirus C |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Hepacivirus C | - |
diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | Hepacivirus C NS5B | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hepacivirus C | - |
- |
- |
Hepacivirus C NS5B | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Hepacivirus C | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | - |
Hepacivirus C NS5B | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HCV NS5B polymerase | - |
Hepacivirus C |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Hepacivirus C |