Protein Variants | Comment | Organism |
---|---|---|
A365N | mutation selected to stabilize the secondary structural elements near the rNTP binding pocket of the enzyme. Mutant viruses were tested in vitro on Vero, C6/36, Culex tarsalis and DF-1 cell types and in vivo in one day old chickens and Culex pipiens mosquitoes. Mutation affects plaque morphology and particularly alters growth and RNA replication kinetics | West Nile virus |
T363N | mutation selected to stabilize the secondary structural elements near the rNTP binding pocket of the enzyme. Mutant viruses were tested in vitro on Vero, C6/36, Culex tarsalis and DF-1 cell types and in vivo in one day old chickens and Culex pipiens mosquitoes. Mutation affects plaque morphology and alters growth and RNA replication kinetics | West Nile virus |
T537I | mutation selected to stabilize the secondary structural elements near the rNTP binding pocket of the enzyme. Mutant viruses were tested in vitro on Vero, C6/36, Culex tarsalis and DF-1 cell types and in vivo in one day old chickens and Culex pipiens mosquitoes. Mutation affects plaque morphology and alters growth and RNA replication kinetics | West Nile virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
West Nile virus | Q8JU43 | viral polyprotein | - |
West Nile virus 3356 | Q8JU43 | viral polyprotein | - |
Synonyms | Comment | Organism |
---|---|---|
NS5 RdRp | - |
West Nile virus |