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Literature summary for 2.7.7.48 extracted from

  • Liu, Z.; Robida, J.M.; Chinnaswamy, S.; Yi, G.; Robotham, J.M.; Nelson, H.B.; Irsigler, A.; Kao, C.C.; Tang, H.
    Mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A (2009), Hepatology, 50, 25-33.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Application

Application Comment Organism
drug development the enzyme is a target for drugs in therapy of HCV infection Hepacivirus C

Protein Variants

Protein Variants Comment Organism
E440G naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
I11V naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
I11V/I454V naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
I432V naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
I454V naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
additional information mutant NS5B DELTA21, produced by cells expressing the HCV replicon, shows increased ability to bind to RNA, with 8fold higher affinity compared to the wild-type, in the presence of cyclosporine A, overview. CsA-resistance mutations locate to two functionally related regions in NS5B structure. Purified recombinant NS5B mutants show higher de novo initiated RNA synthesis than the wild-type control Hepacivirus C
P538T naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
P540A naturally occuring mutation, lethal effect of P540A mutation Hepacivirus C
Q438R naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
Q438R/E440G naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
R556V naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
S556G naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
V405L naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C
W550R naturally occuring mutation, location in the protein and role in RNA binding, overview Hepacivirus C

Inhibitors

Inhibitors Comment Organism Structure
cyclosporine A inhibits HCV replication Hepacivirus C

Organism

Organism UniProt Comment Textmining
Hepacivirus C P26663
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Synonyms

Synonyms Comment Organism
hepatitis C virus polymerase
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 Hepacivirus C
NS5B
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 Hepacivirus C
RDRP
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 Hepacivirus C
RNA-dependent RNA polymerase
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 Hepacivirus C

General Information

General Information Comment Organism
malfunction mutations in the hepatitis C virus polymerase that increase RNA binding can confer resistance to cyclosporine A, an inhibitor that is used as therpeutic against HCV-induced acute and chronic liver disease Hepacivirus C