Literature summary for 2.7.7.48 extracted from

Kozlov, M.V.; Polyakov, K.M.; Ivanov, A.V.; Filippova, S.E.; Kuzyakin, A.O.; Tunitskaya, V.L.; Kochetkov, S.N.
Hepatitis C virus RNA-dependent RNA polymerase: study on the inhibition mechanism by pyrogallol derivatives (2006), Biokhimiia, 71, 1021-1026.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-cyano-N'-[(1Z)-(3,4,5-trihydroxyphenyl)methylene]acetohydrazide	-	Hepacivirus C
3,4,5-trihydroxybenzaldehyde O-methyloxime	-	Hepacivirus C
3-oxo-3-[(2Z)-2-(3,4,5-trihydroxybenzylidene)hydrazino]propanoic acid	-	Hepacivirus C
5'-formylpyrogallol	-	Hepacivirus C
5-((Z)-[(4-methylpiperazin-1-yl)imino]methyl)benzene-1,2,3-triol	-	Hepacivirus C
5-[(Z)-(morpholin-4-ylimino)methyl]benzene-1,2,3-triol	-	Hepacivirus C
5-[(Z)-(phenylimino)methyl]benzene-1,2,3-triol	-	Hepacivirus C
pyrogallol	-	Hepacivirus C
[(2Z)-2-(3,4,5-trihydroxybenzylidene)hydrazino]acetic acid	-	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-

Synonyms

Synonyms	Comment	Organism
HCV RdRp	-	Hepacivirus C

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.003	-	-	Hepacivirus C	3-oxo-3-[(2Z)-2-(3,4,5-trihydroxybenzylidene)hydrazino]propanoic acid
0.005	-	-	Hepacivirus C	5-((Z)-[(4-methylpiperazin-1-yl)imino]methyl)benzene-1,2,3-triol
0.007	-	-	Hepacivirus C	2-cyano-N'-[(1Z)-(3,4,5-trihydroxyphenyl)methylene]acetohydrazide
0.01	-	-	Hepacivirus C	pyrogallol
0.01	-	-	Hepacivirus C	5-[(Z)-(morpholin-4-ylimino)methyl]benzene-1,2,3-triol
0.012	-	-	Hepacivirus C	3,4,5-trihydroxybenzaldehyde O-methyloxime
0.09	-	-	Hepacivirus C	[(2Z)-2-(3,4,5-trihydroxybenzylidene)hydrazino]acetic acid
0.5	-	-	Hepacivirus C	5-[(Z)-(phenylimino)methyl]benzene-1,2,3-triol
1	-	-	Hepacivirus C	5'-formylpyrogallol

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Release 2023.1 (January 2023)