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Literature summary for 2.7.7.47 extracted from

  • Zhang, G.; Leclercq, S.O.; Tian, J.; Wang, C.; Yahara, K.; Ai, G.; Liu, S.; Feng, J.
    A new subclass of intrinsic aminoglycoside nucleotidyltransferases, ANT(3'')-II, is horizontally transferred among Acinetobacter spp. by homologous recombination (2017), PLoS Genet., 13, e1006602 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.47

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli DH5alpha cells Acinetobacter baumannii
expressed in Escherichia coli DH5alpha cells Acinetobacter junii
expressed in Escherichia coli DH5alpha cells Acinetobacter gyllenbergii
expressed in Escherichia coli DH5alpha cells Acinetobacter sp. NIPH 758 (IIb)
expressed in Escherichia coli DH5alpha cells Acinetobacter ursingii
expressed in Escherichia coli DH5alpha cells Acinetobacter pittii
expressed in Escherichia coli DH5alpha cells Acinetobacter parvus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + spectinomycin Acinetobacter baumannii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter junii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter gyllenbergii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter sp. NIPH 758 (IIb)
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter ursingii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter pittii
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter parvus
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter pittii PHEA-2
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter parvus CIP 108168
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter pittii CIP 70.29
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter baumannii ATCC 17978
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter baumannii AYE
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter junii CIP 64.5
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter gyllenbergii NIPH 230
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter ursingii ANC 3649
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin Acinetobacter baumannii ATCC 19606
-
 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + streptomycin Acinetobacter baumannii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter junii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter gyllenbergii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter sp. NIPH 758 (IIb)
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter ursingii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter pittii
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter parvus
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter pittii PHEA-2
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter parvus CIP 108168
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter pittii CIP 70.29
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter baumannii ATCC 17978
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter baumannii AYE
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter junii CIP 64.5
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter gyllenbergii NIPH 230
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter ursingii ANC 3649
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin Acinetobacter baumannii ATCC 19606
-
 diphosphate + 3''-adenylylstreptomycin
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii
-
-
-
Acinetobacter baumannii D0CEM6
-
-
Acinetobacter baumannii Q2FD58
-
-
Acinetobacter baumannii ATCC 17978 Q2FD58
-
-
Acinetobacter baumannii ATCC 19606 D0CEM6
-
-
Acinetobacter baumannii AYE
-
-
-
Acinetobacter gyllenbergii
-
-
-
Acinetobacter gyllenbergii NIPH 230
-
-
-
Acinetobacter junii
-
-
-
Acinetobacter junii CIP 64.5
-
-
-
Acinetobacter parvus
-
-
-
Acinetobacter parvus CIP 108168
-
-
-
Acinetobacter pittii
-
-
-
Acinetobacter pittii CIP 70.29
-
-
-
Acinetobacter pittii PHEA-2
-
-
-
Acinetobacter sp. NIPH 758 (IIb) N8W714
-
-
Acinetobacter ursingii
-
-
-
Acinetobacter ursingii ANC 3649
-
-
-

Purification (Commentary)

Purification (Comment) Organism
His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter baumannii
His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter junii
His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter gyllenbergii
His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter sp. NIPH 758 (IIb)
His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter ursingii
His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter pittii
His-Bind protein column chromatography and Superdex 200 gel filtration Acinetobacter parvus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + spectinomycin
-
 Acinetobacter baumannii diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter junii diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter gyllenbergii diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter sp. NIPH 758 (IIb) diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter ursingii diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter pittii diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter parvus diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter pittii PHEA-2 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter parvus CIP 108168 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter pittii CIP 70.29 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter baumannii ATCC 17978 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter baumannii AYE diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter junii CIP 64.5 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter gyllenbergii NIPH 230 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter ursingii ANC 3649 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + spectinomycin
-
 Acinetobacter baumannii ATCC 19606 diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter baumannii diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter junii diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter gyllenbergii diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter sp. NIPH 758 (IIb) diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter ursingii diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter pittii diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter parvus diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter pittii PHEA-2 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter parvus CIP 108168 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter pittii CIP 70.29 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter baumannii ATCC 17978 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter baumannii AYE diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter junii CIP 64.5 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter gyllenbergii NIPH 230 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter ursingii ANC 3649 diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin
-
 Acinetobacter baumannii ATCC 19606 diphosphate + 3''-adenylylstreptomycin
-
 ?

Synonyms

Synonyms Comment Organism
ANT(3'')-II
-
 Acinetobacter baumannii
ANT(3'')-II
-
 Acinetobacter junii
ANT(3'')-II
-
 Acinetobacter gyllenbergii
ANT(3'')-II
-
 Acinetobacter sp. NIPH 758 (IIb)
ANT(3'')-II
-
 Acinetobacter ursingii
ANT(3'')-II
-
 Acinetobacter pittii
ANT(3'')-II
-
 Acinetobacter parvus

General Information

General Information Comment Organism
malfunction enzyme inactivation decreases streptomycin and spectinomycin resistance by 16fold and 2fold, respectively Acinetobacter baumannii
physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter baumannii
physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter junii
physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter gyllenbergii
physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter sp. NIPH 758 (IIb)
physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter ursingii
physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter pittii
physiological function the enzyme supports streptomycin and spectinomycin resistance Acinetobacter parvus