Literature summary for 2.7.7.43 extracted from

Fujita, A.; Sato, C.; Kitajima, K.
Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase (2007), Biochem. Biophys. Res. Commun., 355, 174-180.

Search for more literature for 2.7.7.43

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in CHO cells, HeLa cells, and NIH-3T3 cells	Mus musculus
expression in CHO cells	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
DELTA408-424	deletion mutant devoid of the second putative nuclear export signal, by immunofluorescent microscopy it is shown that this deletion mutant has an increased nuclear localisation combined with a decreased cytoplasmic localisation	Mus musculus
DELTA61-69	deletion mutant devoid of the first putative nuclear export signal, by immunofluorescent microscopy it is shown that is deletion mutant has an increased nuclear localisation combined with a decreased cytoplasmic localisation	Mus musculus
additional information	by deletion mutant analysis it is demonstrated that mouse CSS contains two nuclear export signals which regulate the transport of the protein from nucleus towards cytosol	Mus musculus
additional information	the two nuclear export signals of mouse CSS are conserved among mammals and fish CSSs but they are not present in bacteria or insect CSS	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Mus musculus	5737	-
cytoplasm	a small, but significant population of the mouse CMP-sialic acid synthetase is also present in cytoplasm	Mus musculus	5737	-
nucleus	vertebrate CSS are usually localised in the nucleus due to a nuclear localisation signal, however in mouse a small proportion of CSS is also present in cytoplasm due to two nuclear export signals	Mus musculus	5634	-
nucleus	mostly localized in nucleus	Mus musculus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99KK2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CTP + N-acylneuraminate	-	Mus musculus	diphosphate + CMP-N-acylneuraminate	-	?

Synonyms

Synonyms	Comment	Organism
CMP-sialic acid synthetase	-	Mus musculus
CSS	-	Mus musculus
mCSS	-	Mus musculus

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Release 2023.1 (January 2023)