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Literature summary for 2.7.7.42 extracted from
- Functional analysis of GlnE, an essential adenylyl transferase in Mycobacterium tuberculosis (2008), J. Bacteriol., 190, 4894-4902.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D438Y/R657S/S684K | temperature-sensitive mutant | Mycobacterium tuberculosis |
| D720A | mutation in the adenylylation domain, compromises activity. Strain shows reduced growth rates in the low-ammonia- and glutamine-containing media | Mycobacterium tuberculosis |
| D732A | mutation in the adenylylation domain, mutation does not completely abrogate the enzyme activity | Mycobacterium tuberculosis |
| V921Q | temperature-sensitive mutant | Mycobacterium tuberculosis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
| Mycobacterium tuberculosis H37Rv | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GlnE | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in the presence of L-methionine sulfoximine, an inhibitor, and glutamine supplementation, a null mutant is able to grow similarly to the wild type. The GlnE mutant is able to survive and grow for extended periods in liquid medium, but not on solid medium, in the absence of glutamine synthetase inhibition | Mycobacterium tuberculosis |
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