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Literature summary for 2.7.7.41 extracted from
- CDP-diacylglycerol synthases (CDS) gateway to phosphatidylinositol and cardiolipin synthesis (2020), Front. Cell Dev. Biol., 8, 63 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| apicoplast | - |
Toxoplasma gondii | 20011 | - |
| apicoplast | - |
Eimeria falciformis | 20011 | - |
| endoplasmic reticulum | - |
Drosophila melanogaster | 5783 | - |
| endoplasmic reticulum | - |
Saccharomyces cerevisiae | 5783 | - |
| endoplasmic reticulum | - |
Schizosaccharomyces pombe | 5783 | - |
| endoplasmic reticulum | - |
Trypanosoma brucei brucei | 5783 | - |
| endoplasmic reticulum | - |
Toxoplasma gondii | 5783 | - |
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Arabidopsis thaliana | 5783 | - |
| endoplasmic reticulum | - |
Eimeria falciformis | 5783 | - |
| Golgi apparatus | - |
Trypanosoma brucei brucei | 5794 | - |
| membrane | integral membrane protein | Drosophila melanogaster | 16020 | - |
| membrane | integral membrane protein | Saccharomyces cerevisiae | 16020 | - |
| membrane | integral membrane protein | Schizosaccharomyces pombe | 16020 | - |
| membrane | integral membrane protein | Thermotoga maritima | 16020 | - |
| membrane | integral membrane protein | Streptococcus mitis | 16020 | - |
| membrane | integral membrane protein | Streptococcus oralis | 16020 | - |
| membrane | integral membrane protein | Trypanosoma brucei brucei | 16020 | - |
| membrane | integral membrane protein | Aeropyrum pernix | 16020 | - |
| membrane | integral membrane protein | Toxoplasma gondii | 16020 | - |
| membrane | integral membrane protein | Homo sapiens | 16020 | - |
| membrane | integral membrane protein | Arabidopsis thaliana | 16020 | - |
| membrane | integral membrane protein | Escherichia coli | 16020 | - |
| membrane | integral membrane protein | Eimeria falciformis | 16020 | - |
| mitochondrion | - |
Danio rerio | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | divalent cations are essential for activity | Schizosaccharomyces pombe |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + phosphatidate | Drosophila melanogaster | - |
diphosphate + CDP-diacylglycerol | - |
? |  |
| CTP + phosphatidate | Saccharomyces cerevisiae | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Schizosaccharomyces pombe | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Thermotoga maritima | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Streptococcus mitis | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Streptococcus oralis | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Trypanosoma brucei brucei | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Aeropyrum pernix | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Toxoplasma gondii | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Homo sapiens | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Arabidopsis thaliana | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Danio rerio | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Escherichia coli | - |
diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | Eimeria falciformis | - |
diphosphate + CDP-diacylglycerol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aeropyrum pernix | - |
- |
- |
| Arabidopsis thaliana | O04928 | - |
- |
| Arabidopsis thaliana | O49639 | - |
- |
| Arabidopsis thaliana | Q1PE48 | - |
- |
| Arabidopsis thaliana | Q94A03 | - |
- |
| Arabidopsis thaliana | Q9M001 | - |
- |
| Danio rerio | Q3B7H2 | - |
- |
| Drosophila melanogaster | - |
- |
- |
| Eimeria falciformis | - |
- |
- |
| Escherichia coli | P0ABG1 | - |
- |
| Homo sapiens | Q92903 | - |
- |
| Homo sapiens | Q95674 | - |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Schizosaccharomyces pombe | - |
- |
- |
| Streptococcus mitis | - |
- |
- |
| Streptococcus oralis | - |
- |
- |
| Thermotoga maritima | - |
- |
- |
| Toxoplasma gondii | - |
- |
- |
| Trypanosoma brucei brucei | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + phosphatidate | - |
Drosophila melanogaster | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Saccharomyces cerevisiae | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Schizosaccharomyces pombe | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Thermotoga maritima | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Streptococcus mitis | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Streptococcus oralis | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Trypanosoma brucei brucei | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Aeropyrum pernix | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Toxoplasma gondii | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Homo sapiens | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Arabidopsis thaliana | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Danio rerio | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Escherichia coli | diphosphate + CDP-diacylglycerol | - |
? | |
| CTP + phosphatidate | - |
Eimeria falciformis | diphosphate + CDP-diacylglycerol | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 27000, SDS-PAGE | Escherichia coli |
| homodimer | 2 * 52000, SDS-PAGE | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CarS | - |
Aeropyrum pernix |
| CDP-DAG synthase | - |
Drosophila melanogaster |
| CDP-DAG synthase | - |
Saccharomyces cerevisiae |
| CDP-DAG synthase | - |
Schizosaccharomyces pombe |
| CDP-DAG synthase | - |
Thermotoga maritima |
| CDP-DAG synthase | - |
Streptococcus mitis |
| CDP-DAG synthase | - |
Streptococcus oralis |
| CDP-DAG synthase | - |
Trypanosoma brucei brucei |
| CDP-DAG synthase | - |
Aeropyrum pernix |
| CDP-DAG synthase | - |
Toxoplasma gondii |
| CDP-DAG synthase | - |
Homo sapiens |
| CDP-DAG synthase | - |
Arabidopsis thaliana |
| CDP-DAG synthase | - |
Danio rerio |
| CDP-DAG synthase | - |
Escherichia coli |
| CDP-DAG synthase | - |
Eimeria falciformis |
| CDP-diacylglycerol synthase | - |
Drosophila melanogaster |
| CDP-diacylglycerol synthase | - |
Saccharomyces cerevisiae |
| CDP-diacylglycerol synthase | - |
Schizosaccharomyces pombe |
| CDP-diacylglycerol synthase | - |
Thermotoga maritima |
| CDP-diacylglycerol synthase | - |
Streptococcus mitis |
| CDP-diacylglycerol synthase | - |
Streptococcus oralis |
| CDP-diacylglycerol synthase | - |
Trypanosoma brucei brucei |
| CDP-diacylglycerol synthase | - |
Aeropyrum pernix |
| CDP-diacylglycerol synthase | - |
Toxoplasma gondii |
| CDP-diacylglycerol synthase | - |
Homo sapiens |
| CDP-diacylglycerol synthase | - |
Arabidopsis thaliana |
| CDP-diacylglycerol synthase | - |
Danio rerio |
| CDP-diacylglycerol synthase | - |
Escherichia coli |
| CDP-diacylglycerol synthase | - |
Eimeria falciformis |
| CDS | - |
Drosophila melanogaster |
| CDS | - |
Saccharomyces cerevisiae |
| CDS | - |
Schizosaccharomyces pombe |
| CDS | - |
Thermotoga maritima |
| CDS | - |
Streptococcus mitis |
| CDS | - |
Streptococcus oralis |
| CDS | - |
Trypanosoma brucei brucei |
| CDS | - |
Aeropyrum pernix |
| CDS | - |
Arabidopsis thaliana |
| CDS | - |
Danio rerio |
| CDS | - |
Escherichia coli |
| CDS | - |
Eimeria falciformis |
| CDS1 | isoform | Toxoplasma gondii |
| CDS1 | isoform | Homo sapiens |
| CDS1 | isoform | Arabidopsis thaliana |
| CDS1 | isoform | Eimeria falciformis |
| CDS2 | isoform | Toxoplasma gondii |
| CDS2 | isoform | Arabidopsis thaliana |
| CDS2 | isoform | Homo sapiens |
| CDS2 | isoform | Eimeria falciformis |
| CDS3 | isoform | Arabidopsis thaliana |
| Cds4 | isoform | Arabidopsis thaliana |
| Cds5 | isoform | Arabidopsis thaliana |
| CdsA | - |
Drosophila melanogaster |
| CdsA | - |
Saccharomyces cerevisiae |
| CdsA | - |
Thermotoga maritima |
| CdsA | - |
Streptococcus mitis |
| CdsA | - |
Streptococcus oralis |
| CdsA | - |
Escherichia coli |
| Tam41 | - |
Schizosaccharomyces pombe |
| TAMM41 | - |
Danio rerio |
| YnbD | - |
Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Schizosaccharomyces pombe |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme knockout causes abnormal heart development, specifically a defect in heart valve formation | Danio rerio |
| malfunction | enzyme mutations cause resistance to daptomycin | Streptococcus mitis |
| malfunction | enzyme mutations cause resistance to daptomycin | Streptococcus oralis |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Drosophila melanogaster |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Saccharomyces cerevisiae |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Schizosaccharomyces pombe |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Thermotoga maritima |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Streptococcus mitis |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Streptococcus oralis |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Trypanosoma brucei brucei |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Aeropyrum pernix |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Toxoplasma gondii |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Homo sapiens |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Arabidopsis thaliana |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Danio rerio |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Escherichia coli |
| metabolism | the enzyme is critical for maintaining phosphoinositide levels during phospholipase C signaling | Eimeria falciformis |
| physiological function | the enzyme is essential for embryogenesis, phototransduction, metamorphosis, and spermatogenesis | Drosophila melanogaster |
| physiological function | the enzyme participates in regulating heart valve formation through mediating PINK1-dependent mitophagy | Danio rerio |
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Release 2023.1 (January 2023)
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