BRENDA - Enzyme Database
show all sequences of 2.7.7.41

CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development

Qi, Y.; Kapterian, T.S.; Du, X.; Ma, Q.; Fei, W.; Zhang, Y.; Huang, X.; Dawes, I.W.; Yang, H.; J. Lipid Res. 57, 767-780 (2016)

Data extracted from this reference:

Engineering
Amino acid exchange
Commentary
Organism
additional information
transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS1 by 81%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells; transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS2 by 90%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
Homo sapiens
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells; transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum membrane
-
Homo sapiens
5789
-
endoplasmic reticulum membrane
-
Mus musculus
5789
-
membrane
-
Homo sapiens
16020
-
membrane
-
Mus musculus
16020
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
CTP + phosphatidate
Mus musculus
-
diphosphate + CDP-diacylglycerol
-
-
?
CTP + phosphatidate
Homo sapiens
-
diphosphate + CDP-diacylglycerol
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
O95674
-
-
Homo sapiens
Q92903
-
-
Mus musculus
P98191
-
-
Mus musculus
Q99L43
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
3T3-L1 cell
;
Mus musculus
-
HeLa cell
;
Homo sapiens
-
preadipocyte
;
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CTP + phosphatidate
-
738826
Mus musculus
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
-
738826
Homo sapiens
diphosphate + CDP-diacylglycerol
-
-
-
?
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS1 by 81%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
Homo sapiens
additional information
transient siRNA knockdown of CDS1 in HeLa cells downregulates CDS2 by 90%. In siCDS2 HeLa cells, the mRNA expression of CDS1 is increased by 2.6fold, but in siCDS1 cells, the CDS2 level is unchanged. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
Homo sapiens
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS1 by 48%. Knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells
Mus musculus
additional information
transient siRNA knockdown of CDS1 in 3T3-L1 cells downregulates CDS2 by 90%. Knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
endoplasmic reticulum membrane
-
Homo sapiens
5789
-
endoplasmic reticulum membrane
-
Mus musculus
5789
-
membrane
-
Homo sapiens
16020
-
membrane
-
Mus musculus
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
CTP + phosphatidate
Mus musculus
-
diphosphate + CDP-diacylglycerol
-
-
?
CTP + phosphatidate
Homo sapiens
-
diphosphate + CDP-diacylglycerol
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
3T3-L1 cell
-
Mus musculus
-
HeLa cell
-
Homo sapiens
-
preadipocyte
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CTP + phosphatidate
-
738826
Mus musculus
diphosphate + CDP-diacylglycerol
-
-
-
?
CTP + phosphatidate
-
738826
Homo sapiens
diphosphate + CDP-diacylglycerol
-
-
-
?
General Information
General Information
Commentary
Organism
malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells; knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
Homo sapiens
malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocked the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells; knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 in 3T3-L1 preadipocytes has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
Mus musculus
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage; CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage
Homo sapiens
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage; CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage; knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocks the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidic acid species are significantly increased upon knocking down CDS1. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2; knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidic acid species are increased upon depleting CDS2. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
Homo sapiens
malfunction
knocking down CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
Homo sapiens
malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocked the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidate species are significantly increased upon knocking down CDS1, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS1, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
Mus musculus
malfunction
knocking down CDS1 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 in 3T3-L1 preadipocytes has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidate species are increased upon depleting CDS2, the amount of phosphatidate in the endoplasmic reticulum is dramatically increased upon knocking down CDS2, overview. The changes in phosphatidate level and localization may underlie the formation of giant lipid droplets as well as the block in adipogenesis in CDS-deficient cells
Mus musculus
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage
Homo sapiens
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage; knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS1 almost completely blocks the differentiation of 3T3-L1 preadipocytes. The levels of many phosphatidic acid species are significantly increased upon knocking down CDS1. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2
Mus musculus
physiological function
CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development, role of CDP-diacylglycerol in lipid storage in mammals. The expansion of lipid droplets and the differentiation of preadipocytes are two important aspects of mammalian lipid storage, CDS1 and CDS2 are important regulators of lipid storage; knocking down either isoform CDS1 or isoform CDS2 results in the formation of giant or supersized lipid droplets in cultured cells. Depleting CDS2 has a moderate inhibitory effect on adipocyte differentiation. Only a small number of phosphatidic acid species are increased upon depleting CDS2. The amount of phosphatidic acid in the endoplasmic reticulum is dramatically increased upon knocking down CDS1 or CDS2
Mus musculus
Other publictions for EC 2.7.7.41
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738826
Qi
CDP-diacylglycerol synthases r ...
Homo sapiens, Mus musculus
J. Lipid Res.
57
767-780
2016
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2
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4
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4
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4
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3
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6
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4
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-
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4
8
-
-
-
737701
DSouza
Distinct properties of the two ...
Homo sapiens
Biochemistry
53
7358-7367
2014
1
-
1
-
-
-
6
3
1
1
-
6
-
3
-
-
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-
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2
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30
-
1
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4
1
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2
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2
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10
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6
2
2
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6
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2
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30
-
2
-
-
4
2
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2
4
-
-
-
739033
He
Increase in cellular triacylgl ...
Schizosaccharomyces japonicus, Schizosaccharomyces japonicus yFS275, Schizosaccharomyces pombe, Schizosaccharomyces pombe 972
Mol. Biol. Cell
25
4083-4095
2014
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1
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2
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4
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6
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4
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4
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2
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-
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6
7
-
-
-
739396
Liu
CDP-diacylglycerol synthetase ...
Drosophila melanogaster
PLoS Genet.
10
e1004172
2014
-
-
-
-
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-
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1
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4
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10
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1
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1
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10
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1
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2
3
-
-
-
741020
Lilley
The essential roles of cytidin ...
Trypanosoma brucei 927, Trypanosoma brucei brucei
Mol. Microbiol.
92
453-470
2014
-
-
1
-
1
-
-
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3
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1
2
-
7
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2
1
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1
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1
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3
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1
2
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-
-
2
1
-
-
-
-
-
-
-
-
-
4
4
-
-
-
723221
Serricchio
Phosphatidylglycerophosphate s ...
Trypanosoma brucei brucei, Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927
Mol. Microbiol.
87
569-579
2013
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-
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2
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-
-
-
-
-
-
1
1
-
-
-
738000
Tamura
Tam41 is a CDP-diacylglycerol ...
Saccharomyces cerevisiae
Cell Metab.
17
709-718
2013
-
-
-
-
2
-
1
4
4
3
-
1
-
3
-
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3
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1
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2
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1
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4
4
3
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1
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3
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-
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-
1
-
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4
4
-
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-
739305
Zhou
Extraplastidial cytidinediphos ...
Arabidopsis thaliana
Plant J.
75
867-879
2013
1
-
1
-
1
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-
-
4
1
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3
-
6
-
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2
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-
14
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2
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3
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2
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2
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9
3
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3
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5
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14
-
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3
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-
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3
8
-
-
-
722903
Waugh
CDP-diacylglycerol phospholipi ...
Homo sapiens
J. Lipid Res.
52
2148-2158
2011
-
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1
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1
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1
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722419
Shastri
Plasmodium CDP-DAG synthase: a ...
Plasmodium falciparum
Int. J. Parasitol.
40
1257-1268
2010
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2
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1
1
1
1
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691056
Laczko-Dobos
Role of phosphatidylglycerol i ...
Synechocystis sp.
Biochim. Biophys. Acta
1777
1184-1194
2008
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1
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1
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690426
Mercade
Characterization and physical ...
Sus scrofa
Anim. Biotechnol.
18
23-35
2007
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6
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1
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1
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1
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659064
Nishibori
Phosphatidylethanolamine domai ...
Bacillus subtilis, Bacillus subtilis Marburg / DSM 10 / ATCC 6051
J. Bacteriol.
187
2163-2174
2005
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1
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7
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4
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661820
Inglis-Broadgate
Isolation and characterization ...
Mus musculus
Gene
356
19-31
2005
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1
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1
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2
2
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5
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1
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9
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4
1
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2
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2
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2
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2
2
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2
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10
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4
2
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Stimulation of cardiac cardiol ...
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643317
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A prototypical cytidylyltransf ...
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1
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643319
Heacock
CDP-diacylglycerol synthase fr ...
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23
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Dowhan
CDP-diacylglycerol synthase of ...
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1997
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Regulation of phospholipid bio ...
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The CDS1 gene encoding CDP-dia ...
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Regulation of PLC-mediated sig ...
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Hanenberg
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Carman
CDPdiacylglycerol synthase fro ...
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CDP-diacylglycerol synthesis i ...
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Bovine brain microsomal CDP-di ...
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Kelley
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CDP-diacylglycerol synthase ac ...
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Liteplo
The stimulation of rat liver m ...
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CTP-phosphatidic acid cytidylt ...
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Partial purification and prope ...
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The influence of exogenous and ...
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Sribney
Studies on the synthesis of CD ...
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Factors controlling the activi ...
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643297
McCaman
Biosynthesis of cytidine dipho ...
Micrococcus cerificans
J. Biol. Chem.
243
5074-5080
1968
3
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5
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5
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1
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1
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1
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1
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3
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1
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1
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1
1
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3
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5
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5
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1
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1
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1
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3
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1
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1
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1
1
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643299
Petzold
The biosynthesis of cytidine d ...
Gallus gallus
J. Biol. Chem.
242
1187-1191
1967
-
-
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-
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3
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1
1
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1
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1
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1
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1
1
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3
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1
1
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1
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1
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1
1
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