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Literature summary for 2.7.7.41 extracted from

  • Saito, S.; Goto, K.; Tonosaki, A.; Kondo, H.
    Gene cloning and characterization of CDP-diacylglycerol synthase from rat brain (1997), J. Biol. Chem., 272, 9503-9509.
    View publication on PubMed
Search for more literature for 2.7.7.41

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
phosphatidylinositol 4,5-bisphosphate strong Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.102
-
 1-stearoyl-2-arachidonoyl-sn-glycero-3-phosphate pH 7.5, 30°C Rattus norvegicus
0.114
-
 1,2-dioleoyl-sn-glycerol 3-phosphate pH 7.5, 30°C Rattus norvegicus
0.138
-
 phosphatidic acid pH 7.5, 30°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the enzyme is mainly localized in close association with the membrane of the endoplasmic reticulum of the transfected cells. Several possible membrane-spanning regions Rattus norvegicus 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O35052
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellar Purkinje cell
-
 Rattus norvegicus
-
photoreceptor inner segment of Rattus norvegicus
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pineal gland
-
 Rattus norvegicus
-
spermatid
-
 Rattus norvegicus
-
spermatocyte postmitotic Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
 Rattus norvegicus diphosphate + CDP-1,2-dioleoylglycerol
-
 ?
CTP + 1-stearoyl-2-arachidonoyl phosphatidic acid
-
 Rattus norvegicus diphosphate + CDP-1-stearoyl-2-arachidonoylglycerol
-
 ?
CTP + phosphatidate the enzyme prefers 1-stearoyl-2-arachidonoyl phosphatidic acid as substrate. Little or no activity is detected towards phosphatidic acids containing saturated fatty acyl groups in both the sn-1 and sn-2 positions Rattus norvegicus diphosphate + CDPdiacylglycerol
-
 ?