BRENDA - Enzyme Database show
show all sequences of 2.7.7.41

Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA

Weeks, R.; Dowhan, W.; Shen, H.; Balantac, N.; Meengs, B.; Nudelman, E.; Leung, D.W.; DNA Cell Biol. 16, 281-289 (1997)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression under the control of a GAL1 promoter in a null cds1 mutant yeast strain complements its growth defect and produces enzyme activity when induced with galactose
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
53226
-
x * 53226, calculation from nucleotide sequence
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CTP + phosphatidate
-
643318
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 53226, calculation from nucleotide sequence
Homo sapiens
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
calculated from nucleotide sequence
-
7.57
Cloned(Commentary) (protein specific)
Commentary
Organism
expression under the control of a GAL1 promoter in a null cds1 mutant yeast strain complements its growth defect and produces enzyme activity when induced with galactose
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
53226
-
x * 53226, calculation from nucleotide sequence
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
CTP + phosphatidate
-
643318
Homo sapiens
diphosphate + CDPdiacylglycerol
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 53226, calculation from nucleotide sequence
Homo sapiens
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
calculated from nucleotide sequence
-
7.57
Other publictions for EC 2.7.7.41
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738826
Qi
CDP-diacylglycerol synthases r ...
Homo sapiens, Mus musculus
J. Lipid Res.
57
767-780
2016
-
-
-
-
2
-
-
-
4
-
-
4
-
4
-
-
-
-
-
3
-
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4
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4
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4
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6
-
-
4
-
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-
-
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-
4
8
-
-
-
737701
DSouza
Distinct properties of the two ...
Homo sapiens
Biochemistry
53
7358-7367
2014
1
-
1
-
-
-
6
3
1
1
-
6
-
3
-
-
-
-
-
-
2
-
30
-
1
-
-
4
1
-
-
-
-
-
-
2
-
2
-
-
-
-
-
10
-
6
2
2
-
6
-
-
-
-
-
-
2
-
30
-
2
-
-
4
2
-
-
-
-
2
4
-
-
-
739033
He
Increase in cellular triacylgl ...
Schizosaccharomyces japonicus, Schizosaccharomyces japonicus yFS275, Schizosaccharomyces pombe, Schizosaccharomyces pombe 972
Mol. Biol. Cell
25
4083-4095
2014
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1
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2
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6
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4
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4
-
2
-
-
-
-
-
-
-
-
6
7
-
-
-
739396
Liu
CDP-diacylglycerol synthetase ...
Drosophila melanogaster
PLoS Genet.
10
e1004172
2014
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
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10
-
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1
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1
-
-
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-
-
10
-
-
1
-
-
-
-
-
-
-
-
-
-
2
3
-
-
-
741020
Lilley
The essential roles of cytidin ...
Trypanosoma brucei, Trypanosoma brucei 927
Mol. Microbiol.
92
453-470
2014
-
-
1
-
1
-
-
-
3
-
-
2
-
7
-
-
-
-
-
-
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-
2
1
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1
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1
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3
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2
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-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
4
4
-
-
-
723221
Serricchio
Phosphatidylglycerophosphate s ...
Trypanosoma brucei, Trypanosoma brucei 927/4 GUTat10.1
Mol. Microbiol.
87
569-579
2013
-
-
-
-
-
-
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-
2
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-
-
-
-
-
-
1
1
-
-
-
738000
Tamura
Tam41 is a CDP-diacylglycerol ...
Saccharomyces cerevisiae
Cell Metab.
17
709-718
2013
-
-
-
-
2
-
1
4
4
3
-
1
-
3
-
-
-
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-
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3
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1
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2
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1
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4
4
3
-
1
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-
-
3
-
-
-
-
-
-
1
-
-
-
4
4
-
-
-
739305
Zhou
Extraplastidial cytidinediphos ...
Arabidopsis thaliana
Plant J.
75
867-879
2013
1
-
1
-
1
-
-
-
4
1
-
3
-
6
-
-
-
-
-
2
-
-
14
-
-
-
-
-
2
-
-
-
-
-
-
3
-
2
-
-
2
-
-
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9
3
-
3
-
-
-
-
-
5
-
-
14
-
-
-
-
-
3
-
-
-
-
3
8
-
-
-
722903
Waugh
CDP-diacylglycerol phospholipi ...
Homo sapiens
J. Lipid Res.
52
2148-2158
2011
-
-
-
-
-
-
-
-
1
-
-
-
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1
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-
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1
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1
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1
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-
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-
-
-
-
-
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-
-
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-
-
-
722419
Shastri
Plasmodium CDP-DAG synthase: a ...
Plasmodium falciparum
Int. J. Parasitol.
40
1257-1268
2010
-
-
-
-
-
-
-
-
2
-
-
-
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4
-
1
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2
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1
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-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
691056
Laczko-Dobos
Role of phosphatidylglycerol i ...
Synechocystis sp.
Biochim. Biophys. Acta
1777
1184-1194
2008
-
-
-
-
1
-
-
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3
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1
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1
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1
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-
690426
Mercade
Characterization and physical ...
Sus scrofa
Anim. Biotechnol.
18
23-35
2007
-
-
-
-
-
-
-
-
-
-
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-
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6
-
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1
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1
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1
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1
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-
-
-
-
659064
Nishibori
Phosphatidylethanolamine domai ...
Bacillus subtilis, Bacillus subtilis Marburg
J. Bacteriol.
187
2163-2174
2005
-
-
1
-
-
-
-
-
1
-
-
2
-
7
-
-
-
-
-
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4
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1
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1
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2
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4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661820
Inglis-Broadgate
Isolation and characterization ...
Mus musculus
Gene
356
19-31
2005
-
-
1
-
-
-
-
-
1
-
2
2
-
5
-
1
-
-
-
9
-
-
4
1
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
2
2
-
-
2
-
-
10
-
-
4
2
-
-
-
-
-
-
-
2
-
-
-
-
-
-
662589
Jiang
Stimulation of cardiac cardiol ...
Mus musculus, Rattus norvegicus
J. Lipid Res.
45
244-252
2004
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
2
-
-
4
-
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-
-
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2
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2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643320
Martin
Characterization of Plasmodium ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
110
93-105
2000
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
1
-
-
-
3
-
-
2
1
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1
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1
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1
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1
-
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3
-
-
2
1
-
-
-
-
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-
-
1
-
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-
-
-
-
643317
Weber
A prototypical cytidylyltransf ...
Bacillus subtilis
Structure Fold. Des.
7
1113-1124
1999
-
-
-
1
-
-
-
-
-
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1
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1
1
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1
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1
1
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-
643318
Weeks
Isolation and expression of an ...
Homo sapiens
DNA Cell Biol.
16
281-289
1997
-
-
1
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
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1
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-
-
1
-
-
-
-
-
-
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1
-
-
-
-
-
-
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-
-
1
1
-
-
-
-
-
-
-
1
-
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-
-
-
-
643319
Heacock
CDP-diacylglycerol synthase fr ...
Cavia porcellus, Drosophila sp., Escherichia coli, Homo sapiens, Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
1348
166-172
1997
-
-
1
-
-
-
-
2
2
3
-
12
-
6
-
-
-
-
-
6
-
-
23
-
-
-
-
-
1
-
-
-
-
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-
-
1
-
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-
-
-
-
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2
2
3
-
12
-
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6
-
-
23
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
643321
Dowhan
CDP-diacylglycerol synthase of ...
Escherichia coli, Saccharomyces cerevisiae
Biochim. Biophys. Acta
1348
157-165
1997
-
-
-
-
-
-
-
-
2
4
1
2
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5
-
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1
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6
-
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2
4
1
2
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6
-
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643322
Monaco
Extraction and stabilization o ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
239
166-170
1997
2
-
-
-
-
-
1
1
1
1
-
-
-
3
-
-
-
-
-
1
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2
1
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1
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2
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1
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1
1
1
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-
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1
-
2
1
-
-
-
1
-
-
-
-
-
-
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-
-
-
-
643323
Lykidis
The role of CDP-diacylglycerol ...
Homo sapiens
J. Biol. Chem.
272
33402-33409
1997
-
-
1
-
-
-
-
-
-
-
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1
-
2
-
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-
-
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-
-
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2
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1
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1
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2
-
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-
-
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-
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-
-
643324
Kopka
Complementary DNAs encoding eu ...
Arabidopsis thaliana, Solanum tuberosum
Plant Physiol.
113
997-1002
1997
-
-
2
-
-
-
-
-
2
-
2
-
-
6
-
-
-
-
-
2
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
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2
-
2
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-
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-
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2
-
-
2
2
-
-
-
-
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-
-
-
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-
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-
643325
Saito
Gene cloning and characterizat ...
Rattus norvegicus
J. Biol. Chem.
272
9503-9509
1997
-
-
1
-
-
-
1
3
1
-
-
-
-
5
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
3
1
-
-
-
-
-
-
-
-
7
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
643328
Shen
Regulation of phospholipid bio ...
Saccharomyces cerevisiae
J. Biol. Chem.
272
11215-11220
1997
-
-
-
-
-
-
-
-
-
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1
-
2
-
-
-
-
-
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-
-
2
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The CDS1 gene encoding CDP-dia ...
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643316
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Regulation of PLC-mediated sig ...
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643300
Sparrow
Purification of CDPdiacylglyce ...
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643301
Carman
CDPdiacylglycerol synthase fro ...
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643302
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CDP-diacylglycerol synthesis i ...
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643298
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Bovine brain microsomal CDP-di ...
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Purification and characterizat ...
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Gaillard
Specific inhibition of phospha ...
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CDP-diacylglycerol synthase ac ...
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Biosynthesis of CDP-diacylglyc ...
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Liteplo
The stimulation of rat liver m ...
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Belendiuk
CTP-phosphatidic acid cytidylt ...
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Langley
Partial purification and prope ...
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Van Heusden
The influence of exogenous and ...
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643305
Sribney
Studies on the synthesis of CD ...
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Sturton
Factors controlling the activi ...
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Bishop
Studies on the formation by ra ...
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McCaman
Biosynthesis of cytidine dipho ...
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Petzold
The biosynthesis of cytidine d ...
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