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Literature summary for 2.7.7.4 extracted from

  • Barrett, K.G.; Fang, H.; Cukovic, D.; Dombkowski, A.A.; Kocarek, T.A.; Runge-Morris, M.
    Upregulation of UGT2B4 expression by 3-phosphoadenosine-5-phosphosulfate synthase knockdown: implications for coordinated control of bile acid conjugation (2015), Drug Metab. Dispos., 43, 1061-1070.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.4

Protein Variants

Protein Variants Comment Organism
additional information knockdown of PAPSS1 and 2 in HepG2 cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + sulfate Homo sapiens
-
 diphosphate + adenylyl sulfate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43252
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sulfate
-
 Homo sapiens diphosphate + adenylyl sulfate
-
 ?

Synonyms

Synonyms Comment Organism
3'-phosphoadenosine-5'-phosphosulfate synthase
-
 Homo sapiens
PAPS synthase
-
 Homo sapiens
PAPSS1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Homo sapiens
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction the suppression of PAPSS1 and 2 decreases the levels of obligate cofactor and sulfate donor PAPS and reduce cellular sulfotransferase activity. Endogenous SULT2A1 is not upregulated in PAPSS1/2 double knockdown HepG2 cells, whereas the amount of UGT2B4 mRNA is significantly increased. Mechanism(s) responsible for the PAPSS1/2 knockdown-mediated upregulation of human UGT2B4, overview Homo sapiens