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Literature summary for 2.7.7.39 extracted from
- CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered bi-bi reaction mechanism with micromolar K(m) values (2003), Biochim. Biophys. Acta, 1646, 196-206.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Staphylococcus aureus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CDPglycerol | mixed inhibition with CTP and glycerol 3-phosphate as substrates | Staphylococcus aureus |  |
| diphosphate | mixed inhibition with CTP as substrate | Staphylococcus aureus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0014 | - |
glycerol 3-phosphate | pH 8 | Staphylococcus aureus | |
| 0.036 | - |
CTP | pH 8 | Staphylococcus aureus | |
| 9.7 | - |
diphosphate | pH 8, reverse reaction | Staphylococcus aureus | |
| 60 | - |
CDPglycerol | pH 8, reverse reaction | Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + sn-glycerol 3-phosphate | Staphylococcus aureus | - |
diphosphate + CDPglycerol | - |
r | |
| CTP + sn-glycerol 3-phosphate | Saccharomyces cerevisiae | - |
diphosphate + CDPglycerol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Staphylococcus aureus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol | mechanism | Staphylococcus aureus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + sn-glycerol 3-phosphate | - |
Staphylococcus aureus | diphosphate + CDPglycerol | - |
r | |
| CTP + sn-glycerol 3-phosphate | - |
Saccharomyces cerevisiae | diphosphate + CDPglycerol | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
CDPglycerol | pH 8, reverse reaction | Staphylococcus aureus | |
| 2.6 | - |
CTP | pH 8, forward reaction | Staphylococcus aureus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Staphylococcus aureus |
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Release 2023.1 (January 2023)
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