Literature summary for 2.7.7.38 extracted from

Claesson, A.; Luthman, K.; Gustafsson, K.; Bondesson, G.
A 2-deoxy analogue of KDO as the first inhibitor of the enzyme CMP-KDO synthetase (1987), Biochem. Biophys. Res. Commun., 143, 1063-1068.

Search for more literature for 2.7.7.38

Inhibitors

Inhibitors	Comment	Organism	Structure
2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate	2-deoxy KDO analog	Escherichia coli
2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate	2-deoxy KDO analog	Salmonella enterica subsp. enterica serovar Typhimurium
additional information	no inhibition with 3-deoxy-D-manno-octulosonate analog 2,6-anhydro-3-deoxy-D-glycero-D-galacto-octanoate	Escherichia coli
additional information	no inhibition with 3-deoxy-D-manno-octulosonate analog 2,6-anhydro-3-deoxy-D-glycero-D-galacto-octanoate	Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CTP + 3-deoxy-D-manno-octulosonate	Salmonella enterica subsp. enterica serovar Typhimurium	-	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r
CTP + 3-deoxy-D-manno-octulosonate	Escherichia coli	-	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r
CTP + 3-deoxy-D-manno-octulosonate	Escherichia coli D21	-	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r
CTP + 3-deoxy-D-manno-octulosonate	Salmonella enterica subsp. enterica serovar Typhimurium SL 1102	-	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Escherichia coli D21	-	-	-
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-
Salmonella enterica subsp. enterica serovar Typhimurium SL 1102	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CTP + 3-deoxy-D-manno-octulosonate	-	Salmonella enterica subsp. enterica serovar Typhimurium	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r
CTP + 3-deoxy-D-manno-octulosonate	-	Escherichia coli	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r
CTP + 3-deoxy-D-manno-octulosonate	-	Escherichia coli D21	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r
CTP + 3-deoxy-D-manno-octulosonate	-	Salmonella enterica subsp. enterica serovar Typhimurium SL 1102	diphosphate + CMP-3-deoxy-D-manno-octulosonate	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0039	-	2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate	-	Salmonella enterica subsp. enterica serovar Typhimurium
0.0039	-	2,6-Anhydro-3-deoxy-D-glycero-D-talo-octanoate	-	Escherichia coli

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Release 2023.1 (January 2023)