Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CDPparatose | synonym: 3,6-dideoxy-D-glucose, feed-back inhibition, CDPglucose partially reverses, maximal inhibition at 0.6 mM | Salmonella enterica subsp. enterica serovar Paratyphi A | |
additional information | little or no inhibition by CMP, GDPglucose, UDPglucose, dTDPglucose; no inhibition by NaF, diphosphatase, 2-mercaptoethanol, paratose, CTP | Salmonella enterica subsp. enterica serovar Paratyphi A |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.015 | - |
CDPglucose | pH 8, 37°C | Salmonella enterica subsp. enterica serovar Paratyphi A | |
0.034 | - |
CTP | pH 8, 37°C | Salmonella enterica subsp. enterica serovar Paratyphi A | |
0.09 | - |
alpha-D-glucose 1-phosphate | pH 8, 37°C | Salmonella enterica subsp. enterica serovar Paratyphi A | |
0.1 | - |
diphosphate | pH 8, 37°C | Salmonella enterica subsp. enterica serovar Paratyphi A |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Salmonella enterica subsp. enterica serovar Paratyphi A | |
Mg2+ | optimal concentration: 3 mM MgCl2 | Salmonella enterica subsp. enterica serovar Paratyphi A |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + D-glucose 1-phosphate | Salmonella enterica subsp. enterica serovar Paratyphi A | branch-point in glucose 1-phosphate anabolism | ? | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Paratyphi A | - |
strain a | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.408 | - |
- |
Salmonella enterica subsp. enterica serovar Paratyphi A |
Storage Stability | Organism |
---|---|
-20°C, about 30% loss of activity within 1 month | Salmonella enterica subsp. enterica serovar Paratyphi A |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + alpha-D-glucose 1-phosphate | no substrates in the reverse reaction: ADPglucose, dTDPglucose, UDPglucose | Salmonella enterica subsp. enterica serovar Paratyphi A | diphosphate + CDPglucose | - |
r | |
CTP + alpha-D-glucose 1-phosphate | no substrate in the reverse reaction: CDPparatose | Salmonella enterica subsp. enterica serovar Paratyphi A | diphosphate + CDPglucose | - |
r | |
CTP + alpha-D-glucose 1-phosphate | no substrate in the forward reaction: alpha-D-mannose 1-phosphate, N-acetyl-alpha-D-glucosamine 1-phosphate | Salmonella enterica subsp. enterica serovar Paratyphi A | diphosphate + CDPglucose | - |
r | |
CTP + alpha-D-glucose 1-phosphate | specific for base and sugar | Salmonella enterica subsp. enterica serovar Paratyphi A | diphosphate + CDPglucose | - |
r | |
CTP + alpha-D-glucose 1-phosphate | no substrate in the forward reaction: GTP and D-mannose 1-phosphate | Salmonella enterica subsp. enterica serovar Paratyphi A | diphosphate + CDPglucose | - |
r | |
CTP + alpha-D-glucose 1-phosphate | no substrates in the reverse reaction: GDPglucose | Salmonella enterica subsp. enterica serovar Paratyphi A | diphosphate + CDPglucose | - |
r | |
CTP + D-glucose 1-phosphate | branch-point in glucose 1-phosphate anabolism | Salmonella enterica subsp. enterica serovar Paratyphi A | ? | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Salmonella enterica subsp. enterica serovar Paratyphi A |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Salmonella enterica subsp. enterica serovar Paratyphi A |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.2 | 9.5 | about half-maximal activity at pH 6.2 and about 70% of maximal activity at pH 9.5 | Salmonella enterica subsp. enterica serovar Paratyphi A |