Application | Comment | Organism |
---|---|---|
drug development | the enzyme is an attractive target for antibacterial drug development against Helicobacter pylori | Helicobacter pylori |
medicine | the enzyme is a therapeutical target in treatment of Helicobacter induced gastritis | Helicobacter pylori |
Cloned (Comment) | Organism |
---|---|
recombinant expression in Escherichia coli strain BL21(DE3) | Helicobacter pylori |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AC1LDVWJ | - |
Helicobacter pylori | |
D-amethopterin | a mixed-type inhibitor of HpPPAT activity, that simultaneously occupies the HpPPAT 4'-phosphopantetheine- and ATP-binding sites, the compound can serve as a lead compound in drug development, steady-state kinetic inhibition assay. Model of HpPPAT complexed with D-amethopterin, overview | Helicobacter pylori | |
additional information | inhibitor virtual high-throughput screening using the HpPPAT crystal structure, docking study, overview | Helicobacter pylori | |
Omeprazole | - |
Helicobacter pylori | |
T5568746 | - |
Helicobacter pylori | |
zanamivir | - |
Helicobacter pylori |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Helicobacter pylori |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pantetheine 4'-phosphate | Helicobacter pylori | - |
diphosphate + 3'-dephospho-CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Helicobacter pylori | O26010 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + pantetheine 4'-phosphate | - |
Helicobacter pylori | diphosphate + 3'-dephospho-CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphopantetheine adenylyltransferase | - |
Helicobacter pylori |
PPAT | - |
Helicobacter pylori |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Helicobacter pylori |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Helicobacter pylori |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2674 | - |
D-amethopterin | pH 7.9, 25°C, recombinant enzyme | Helicobacter pylori |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme inactivation effectively prevents bacterial viability | Helicobacter pylori |
metabolism | the enzyme catalyzes the penultimate step in coenzyme A biosynthesis | Helicobacter pylori |