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Literature summary for 2.7.7.28 extracted from

  • Hansen, R.G.; Verachtert, H.; Rodriguez, P.; Bass, S.T.
    GDP-hexose pyrophosphorylase from liver (1966), Methods Enzymol., 8, 269-271.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
D-mannose 1-phosphate
-
Bos taurus
GDPmannose
-
Bos taurus
Zn2+ inhibits when added with Mg2+, Mn2+ or Co2+ Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0001
-
GDPmannose
-
Bos taurus
0.082
-
diphosphate
-
Bos taurus
2.6
-
GTP
-
Bos taurus
2.6
-
D-glucose 1-phosphate
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Bos taurus
Mn2+ metal requirement can be partially met by Mn2+ Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose ATP + D-mannose 1-phosphate
-
?
GDP-glucose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose GTP + D-glucose 1-phosphate
-
r
GDPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose GTP + D-mannose 1-phosphate
-
?
IDP-glucose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose ITP + D-glucose 1-phosphate
-
?
IDPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose ITP + D-mannose 1-phosphate
-
r
UDPglucose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose UTP + D-glucose 1-phosphate
-
?
UDPmannose + diphosphate Bos taurus the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose UTP + D-mannose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.38
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus ATP + D-mannose 1-phosphate
-
?
GDP-glucose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus GTP + D-glucose 1-phosphate
-
r
GDPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus GTP + D-mannose 1-phosphate
-
?
IDP-glucose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus ITP + D-glucose 1-phosphate
-
?
IDPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus ITP + D-mannose 1-phosphate
-
r
UDPglucose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus UTP + D-glucose 1-phosphate
-
?
UDPmannose + diphosphate the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose Bos taurus UTP + D-mannose 1-phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00017
-
GDP-mannose
-
Bos taurus
0.047
-
D-mannose 1-phosphate
-
Bos taurus