Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-mannose 1-phosphate | - |
Bos taurus | |
GDPmannose | - |
Bos taurus | |
Zn2+ | inhibits when added with Mg2+, Mn2+ or Co2+ | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0001 | - |
GDPmannose | - |
Bos taurus | |
0.082 | - |
diphosphate | - |
Bos taurus | |
2.6 | - |
GTP | - |
Bos taurus | |
2.6 | - |
D-glucose 1-phosphate | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Bos taurus | |
Mn2+ | metal requirement can be partially met by Mn2+ | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADPmannose + diphosphate | Bos taurus | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | ATP + D-mannose 1-phosphate | - |
? | |
GDP-glucose + diphosphate | Bos taurus | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | GTP + D-glucose 1-phosphate | - |
r | |
GDPmannose + diphosphate | Bos taurus | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | GTP + D-mannose 1-phosphate | - |
? | |
IDP-glucose + diphosphate | Bos taurus | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | ITP + D-glucose 1-phosphate | - |
? | |
IDPmannose + diphosphate | Bos taurus | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | ITP + D-mannose 1-phosphate | - |
r | |
UDPglucose + diphosphate | Bos taurus | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | UTP + D-glucose 1-phosphate | - |
? | |
UDPmannose + diphosphate | Bos taurus | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | UTP + D-mannose 1-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.38 | - |
- |
Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADPmannose + diphosphate | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | Bos taurus | ATP + D-mannose 1-phosphate | - |
? | |
GDP-glucose + diphosphate | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | Bos taurus | GTP + D-glucose 1-phosphate | - |
r | |
GDPmannose + diphosphate | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | Bos taurus | GTP + D-mannose 1-phosphate | - |
? | |
IDP-glucose + diphosphate | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | Bos taurus | ITP + D-glucose 1-phosphate | - |
? | |
IDPmannose + diphosphate | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | Bos taurus | ITP + D-mannose 1-phosphate | - |
r | |
UDPglucose + diphosphate | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | Bos taurus | UTP + D-glucose 1-phosphate | - |
? | |
UDPmannose + diphosphate | the enzyme catalyzes the pyrophosphorolysis of the following nucleoside diphosphate hexoses in decreasing order of activity: GDPglucose, GDPmannose, IDPmannose, IDPglucose, ADPmannose, UDPglucose and UDPmannose | Bos taurus | UTP + D-mannose 1-phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | - |
Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00017 | - |
GDP-mannose | - |
Bos taurus | |
0.047 | - |
D-mannose 1-phosphate | - |
Bos taurus |