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Literature summary for 2.7.7.27 extracted from
- Investigation of the interaction between the large and small subunits of potato ADP-glucose pyrophosphorylase (2009), PLoS Comput. Biol., 5, e1000546.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3-Phosphoglyceric acid | - |
Solanum tuberosum |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the cDNAs of potato AGPase LS and SS are PCR amplified using pML7 and pML10 plasmids as template, respectively, and ligated into pGADT7 and pGBKT7 vectors for the yeast two-hybrid assay | Solanum tuberosum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| LSH342A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSH89A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSI330K | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSI335R | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSI339A/I330A | large subunit mutant, substitution of critical amino acids regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSK334A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSK336A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSN102A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSN87A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSP327A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSR45A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSR88A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSR92A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LST328A/I330A | large subunit mutant, substitution of critical amino acids regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSW135A | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
| LSW135R | large subunit mutant, substitution of a critical amino acid regarding the formation of the native heterotetrameric enzyme | Solanum tuberosum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| inorganic phosphate | - |
Solanum tuberosum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Solanum tuberosum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 207000 | - |
heterotetramer, determined by SDS-PAGE and Western blot analysis | Solanum tuberosum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-D-glucose 1-phosphate | Solanum tuberosum | - |
diphosphate + ADP-glucose | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Solanum tuberosum | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| tuber | - |
Solanum tuberosum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + alpha-D-glucose 1-phosphate | - |
Solanum tuberosum | diphosphate + ADP-glucose | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterotetramer | the enzyme is composed of pairs of large, LS, and small subunits, SS | Solanum tuberosum |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADP-glucose pyrophosphorylase | - |
Solanum tuberosum |
| AGPase | - |
Solanum tuberosum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Solanum tuberosum | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ADP-glucose pyrophosphorylase is a key allosteric enzyme involved in higher plants starch biosynthesis | Solanum tuberosum |
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