Protein Variants | Comment | Organism |
---|---|---|
D208A | UDP-N-acetylglucosamine diphosphorylase activity is very low | Sulfurisphaera tokodaii |
E146A | UDP-N-acetylglucosamine diphosphorylase activity is very low | Sulfurisphaera tokodaii |
G9A | UDP-N-acetylglucosamine diphosphorylase activity is very low | Sulfurisphaera tokodaii |
K147A | UDP-N-acetylglucosamine diphosphorylase activity is very low | Sulfurisphaera tokodaii |
R13A | UDP-N-acetylglucosamine diphosphorylase activity is very low | Sulfurisphaera tokodaii |
T80A | enhanced UDP-N-acetylglucosamine diphosphorylase activity under optimal conditions | Sulfurisphaera tokodaii |
Y97A | enhanced UDP-N-acetylglucosamine diphosphorylase activity under optimal conditions | Sulfurisphaera tokodaii |
Y97F | UDP-N-acetylglucosamine diphosphorylase activity is very low | Sulfurisphaera tokodaii |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 2 mM. Activation of UDP-N-acetylglucosamine diphosphorylase activity in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Zn2+, Ca2+. No activity is detectable without a divalent cation | Sulfurisphaera tokodaii | |
Co2+ | 2 mM. Activation of UDP-N-acetylglucosamine diphosphorylase activity in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Zn2+, Ca2+. No activity is detectable without a divalent cation | Sulfurisphaera tokodaii | |
Mg2+ | 2 mM. Activation of UDP-N-acetylglucosamine diphosphorylase activity in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Zn2+, Ca2+. No activity is detectable without a divalent cation | Sulfurisphaera tokodaii | |
Mn2+ | 2 mM. Activation of UDP-N-acetylglucosamine diphosphorylase activity in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Zn2+, Ca2+. No activity is detectable without a divalent cation | Sulfurisphaera tokodaii | |
Zn2+ | 2 mM. Activation of UDP-N-acetylglucosamine diphosphorylase activity in the order of decreasing effectiveness: Co2+, Mn2+, Mg2+, Zn2+, Ca2+. No activity is detectable without a divalent cation | Sulfurisphaera tokodaii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Sulfurisphaera tokodaii | the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms | ? | - |
? | |
additional information | Sulfurisphaera tokodaii 7 | the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sulfurisphaera tokodaii | Q975F9 | - |
- |
Sulfurisphaera tokodaii 7 | Q975F9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dTTP + alpha-D-glucose 1-phosphate | the enzyme also shows activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase | Sulfurisphaera tokodaii | diphosphate + dTDP-alpha-D-glucose | - |
? | |
dTTP + alpha-D-glucose 1-phosphate | the enzyme also shows activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase | Sulfurisphaera tokodaii 7 | diphosphate + dTDP-alpha-D-glucose | - |
? | |
additional information | the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms | Sulfurisphaera tokodaii | ? | - |
? | |
additional information | the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms | Sulfurisphaera tokodaii 7 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glc-1-P TTase | - |
Sulfurisphaera tokodaii |
ST0452 | locus name | Sulfurisphaera tokodaii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
80 | - |
assay at | Sulfurisphaera tokodaii |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
80 | - |
half-life: 180 min | Sulfurisphaera tokodaii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Sulfurisphaera tokodaii |
General Information | Comment | Organism |
---|---|---|
physiological function | the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms | Sulfurisphaera tokodaii |