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Literature summary for 2.7.7.23 extracted from

  • Bais, V.S.; Aggarwal, P.; Bharadwaj, P.; Prakash, B.
    Classification, characterization and structural analysis of sugar nucleotidylyltransferase family of enzymes (2020), Biochem. Biophys. Res. Commun., 525, 780-785 .
    View publication on PubMed
Search for more literature for 2.7.7.23

Protein Variants

Protein Variants Comment Organism
K421A the activity of the mutant is very low (less than 5%) in comparison to the wild type enzyme Candida albicans
N239A the activity of the mutant is very low (less than 10%) in comparison to the wild type enzyme Mycobacterium tuberculosis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ strictly required. One magnesium ion catalyzes the sugar-nucleotidyl transfer reaction. 5 mM used in assay conditions Candida albicans
Mg2+ strictly required. Two magnesium ions catalyze the sugar-nucleotidyl transfer reaction. 5 mM used in assay conditions Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Candida albicans
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Mycobacterium tuberculosis H37Rv
-
 diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Candida albicans O74933
-
-
Mycobacterium tuberculosis P9WMN3
-
-
Mycobacterium tuberculosis H37Rv P9WMN3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Candida albicans diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
 Mycobacterium tuberculosis H37Rv diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
 ?

Synonyms

Synonyms Comment Organism
GlmU
-
 Mycobacterium tuberculosis
N-acetylglucosamine-1-phosphate uridyltransferase
-
 Mycobacterium tuberculosis
N-acetylglucosamine-1-phosphate uridyltransferase
-
 Candida albicans
UAP1
-
 Candida albicans