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Literature summary for 2.7.7.23 extracted from

  • Qi, X.; Deng, W.; Gao, M.; Mao, B.; Xu, S.; Chen, C.; Zhang, Q.
    Novel lead compound optimization and synthesized based on the target structure of Xanthomonas oryzae pv. oryzae GlmU (2015), Pestic. Biochem. Physiol., 122, 22-28.
    View publication on PubMed

Application

Application Comment Organism
drug development N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is an attractive target for the development of antimicrobial agents Xanthomonas oryzae pv. oryzae

Inhibitors

Inhibitors Comment Organism Structure
additional information for development of potent and selective inhibitors of the uridyltransferase activity of Xanthomonas oryzae pv. oryzae GlmU, three types of target compounds are optimized and synthesized based on the Xo-GlmU structure, docking stud, and biological activity evaluation, overview Xanthomonas oryzae pv. oryzae
N1',N3'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N3'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N3'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N3'-bis(2-(naphthalen-2-yloxy)acetyl) isophthalohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N4'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N4'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N4'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N4'-bis(2-(naphthalen-2-yloxy)acetyl) succinohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N6'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N6'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N6'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
-
Xanthomonas oryzae pv. oryzae
N1',N6'-bis(2-(naphthalen-2-yloxy)acetyl)adipohydrazide
-
Xanthomonas oryzae pv. oryzae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Xanthomonas oryzae pv. oryzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate Xanthomonas oryzae pv. oryzae
-
diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
?

Organism

Organism UniProt Comment Textmining
Xanthomonas oryzae pv. oryzae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UTP + N-acetyl-alpha-D-glucosamine 1-phosphate
-
Xanthomonas oryzae pv. oryzae diphosphate + UDP-N-acetyl-alpha-D-glucosamine
-
?

Synonyms

Synonyms Comment Organism
GlmU
-
Xanthomonas oryzae pv. oryzae
N-acetylglucosamine-1-phosphate uridyltransferase
-
Xanthomonas oryzae pv. oryzae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Xanthomonas oryzae pv. oryzae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Xanthomonas oryzae pv. oryzae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0108
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
0.0112
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
0.0125
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
0.0134
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(6-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
0.0138
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(naphthalen-2-yloxy)acetyl) isophthalohydrazide
0.0154
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
0.0171
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(naphthalen-2-yloxy)acetyl) succinohydrazide
0.0184
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N3'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)isophthalohydrazide
0.0194
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N4'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)succinohydrazide
0.022
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(3-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
0.0233
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(1-bromonaphthalen naphthalen-2-yloxy)acetyl)adipohydrazide
0.0332
-
pH 7.5, 37°C Xanthomonas oryzae pv. oryzae N1',N6'-bis(2-(naphthalen-2-yloxy)acetyl)adipohydrazide