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Literature summary for extracted from

  • Rossi, F.; Geiszler, P.C.; Meng, W.; Barron, M.R.; Prior, M.; Herd-Smith, A.; Loreto, A.; Lopez, M.Y.; Faas, H.; Pardon, M.C.; Conforti, L.
    NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy (2018), Behav. Brain Res., 339, 140-152 .
    View publication on PubMedView publication on EuropePMC


Organism UniProt Comment Textmining
Mus musculus Q9EPA7 isoform NMNAT1, cf. EC


Synonyms Comment Organism
NMNAT1 cf. EC Mus musculus

General Information

General Information Comment Organism
physiological function crossing of htau mice, which express non-mutant human tau isoforms and represent a model of tauopathy relevant to Alzheimer's disease, with Nmnat1 transgenic and knockout mice. In the resulting offspring until the age of 6 months, overexpression of NMNAT1 ameliorates the early deficit in food burrowing characteristic of htau mice. At 6 months of age, htau mice do not show neurodegenerative changes in both the cortex and hippocampus, and these are not induced by downregulating NMNAT1 levels. Modulating NMNAT1 levels produces a corresponding effect on NMNAT enzymatic activity but does not alter NAD levels in htau mice Mus musculus