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Literature summary for 2.7.7.15 extracted from

  • Moitra, S.; Pawlowic, M.C.; Hsu, F.F.; Zhang, K.
    Phosphatidylcholine synthesis through cholinephosphate cytidylyltransferase is dispensable in Leishmania major (2019), Sci. Rep., 9, 7602 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.15

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum mainly located in the endoplasmic reticulum Leishmania major 5783
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + phosphocholine Leishmania major
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 diphosphate + CDP-choline
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania major Q4QDQ6
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + phosphocholine
-
 Leishmania major diphosphate + CDP-choline
-
 ?

Synonyms

Synonyms Comment Organism
cholinephosphate cytidylyltransferase
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 Leishmania major
cpcT
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 Leishmania major
LmjF.18.1330
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 Leishmania major

General Information

General Information Comment Organism
malfunction without cholinephosphate cytidylyltransferase (CPCT), Leishmania major parasites cannot incorporate choline into phosphatidylcholine, yet the CPCT-null mutants contain similar levels of phosphatidylcholine and phosphatidylethanolamine as wild type parasites. Loss of CPCT does not affect the growth of parasites in complete medium or their virulence in mice. The results suggest that other mechanisms of phosphatidylcholine synthesis can compensate the loss of CPCT. CPCT-null parasites exhibit severe growth defects when ethanolamine and exogenous lipids became limited or when they are co-cultured with certain bacteria that are known to be members of sandfly midgut microbiota Leishmania major
metabolism the enzyme catalyzes the formation of CDP-choline, a key intermediate in the choline branch of the Kennedy pathway Leishmania major