Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
additional information | immunohistochemic analysis of enzyme subcellular localization, overview | Cricetulus griseus | - |
- |
additional information | immunohistochemic analysis of enzyme subcellular localization, overview | Homo sapiens | - |
- |
nucleoplasm | - |
Homo sapiens | 5654 | - |
nucleoplasm | in CHO cells, CCTalpha is nucleoplasmic and colocalized with GFP-progerin in nuclear folds and invaginations | Cricetulus griseus | 5654 | - |
nucleoplasmic reticulum | - |
Cricetulus griseus | 44195 | - |
nucleoplasmic reticulum | - |
Homo sapiens | 44195 | - |
nucleus | lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation | Cricetulus griseus | 5634 | - |
nucleus | lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + phosphocholine | Cricetulus griseus | - |
diphosphate + CDP-choline | - |
? | |
CTP + phosphocholine | Homo sapiens | - |
diphosphate + CDP-choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
fibroblast | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + phosphocholine | - |
Cricetulus griseus | diphosphate + CDP-choline | - |
? | |
CTP + phosphocholine | - |
Homo sapiens | diphosphate + CDP-choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CCTalpha | - |
Cricetulus griseus |
CCTalpha | - |
Homo sapiens |
CTP:phosphocholine cytidylyltransferase alpha | - |
Cricetulus griseus |
CTP:phosphocholine cytidylyltransferase alpha | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | CTP:phosphocholine cytidylyltransferase alpha is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine synthesis. Lipid activation of the enzyme results in its translocation to the nuclear envelope and expansion of an intranuclear membrane network termed the nucleoplasmic reticulum by a mechanism involving membrane deformation. CCTalpha and lamins specifically cooperate to form the nucleoplasmic reticulum, but the overall structure of the nuclear envelope has a minimal impact on enzyme activity and phosphocholine synthesis | Cricetulus griseus |
physiological function | CTP:phosphocholine cytidylyltransferase alpha is a nuclear enzyme that catalyzes the rate-limiting step in the CDP-choline pathway for phosphatidylcholine synthesis. The enzyme is not involved in the Hutchinson-Gilford progeria syndrome, overview | Homo sapiens |