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Literature summary for 2.7.7.15 extracted from

  • Hastings, C.; Rand, T.; Bergen, H.T.; Thliveris, J.A.; Shaw, A.R.; Lombaert, G.A.; Mantsch, H.H.; Giles, B.L.; Dakshinamurti, S.; Scott, J.E.
    Stachybotrys chartarum alters surfactant-related phospholipid synthesis and CTP:cholinephosphate cytidylyltransferase activity in isolated fetal rat type II cells (2005), Toxicol. Sci., 84, 186-194.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Lipids regulation of activity by reversible association with membrane lipids Rattus norvegicus
phosphatidylglycerol
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibited with spore extract from Stachybotrys chartarum isolated in Cleveland, no effect with extracts from the same organism isolated in Hawaii Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane enzyme is activated when bound to vesicles Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + choline phosphate Rattus norvegicus rate limiting enzyme for the synthesis of phosphatidylcholine diphosphate + CDP-choline
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
fetal Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
lung isolated fetal rat type II cells Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate
-
Rattus norvegicus diphosphate + CDP-choline
-
?
CTP + choline phosphate rate limiting enzyme for the synthesis of phosphatidylcholine Rattus norvegicus diphosphate + CDP-choline
-
?