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Literature summary for 2.7.7.15 extracted from
- Cytidine-5'-diphosphocholine affects CTP-phosphocholine cytidylyltransferase and lyso-phosphatidylcholine after transient brain ischemia (2004), J. Neurosci. Res., 76, 390-396.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Lipids | regulation of activity by reversible association with membrane lipids | Meriones unguiculatus | |
| additional information | CDP-choline increases enzyme activity after induction of ischemia | Meriones unguiculatus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| lyso-phosphatidylcholine | - |
Meriones unguiculatus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | distributed between cytosol and membrane, lipid environment required for activity | Meriones unguiculatus | 5737 | - |
| membrane | distributed between cytosol and membrane, lipid environment required for activity | Meriones unguiculatus | 16020 | - |
| membrane | enzyme is activated when bound to vesicles | Meriones unguiculatus | 16020 | - |
| nucleus | - |
Meriones unguiculatus | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | Meriones unguiculatus | rate limiting enzyme for the synthesis of phosphatidylcholine | diphosphate + CDP-choline | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Meriones unguiculatus | - |
male Mongolian gerbil, induction of brain ischemia resulted in loss of enzyme activity in cytosol and membrane | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Meriones unguiculatus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Meriones unguiculatus | diphosphate + CDP-choline | - |
? | |
| CTP + choline phosphate | rate limiting enzyme for the synthesis of phosphatidylcholine | Meriones unguiculatus | diphosphate + CDP-choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCTalpha | nuclear protein, soluble | Meriones unguiculatus |
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Release 2023.1 (January 2023)
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