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Literature summary for 2.7.7.15 extracted from

  • Rock, C.O.; Heath, R.J.; Park, H.W.; Jackowski, S.
    The licC gene of Streptococcus pneumoniae encodes a CTP:phosphocholine cytidylyltransferase (2001), J. Bacteriol., 183, 4927-4931.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.15

Cloned(Commentary)

Cloned (Comment) Organism
-
 Streptococcus pneumoniae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.083
-
 phosphocholine pH 7, 37°C Streptococcus pneumoniae
0.133
-
 CTP pH 7, 37°C Streptococcus pneumoniae
1.43
-
 Phosphoethanolamine pH 7, 37°C Streptococcus pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 SDS-PAGE, gel filtration Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + choline phosphate Streptococcus pneumoniae plays a role in the biosynthesis of the phosphocholine-derivatized cell wall constituents that are critical for cell separation and pathogenesis diphosphate + CDPcholine
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus pneumoniae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5
-
-
 Streptococcus pneumoniae

Storage Stability

Storage Stability Organism
-20°C stable for several months in 50% glycerol/20 mM Tris pH 7.5 Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + choline phosphate ATP can replace CTP with less efficiency Streptococcus pneumoniae diphosphate + CDPcholine
-
 ?
CTP + choline phosphate plays a role in the biosynthesis of the phosphocholine-derivatized cell wall constituents that are critical for cell separation and pathogenesis Streptococcus pneumoniae diphosphate + CDPcholine
-
 ?
CTP + ethanolamine phosphate poor substrate Streptococcus pneumoniae diphosphate + CDPethanolamine
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 30000, SDS-PAGE Streptococcus pneumoniae