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Literature summary for 2.7.7.15 extracted from
- Substrate specificity of CTP:phosphocholine cytidylyltransferase (1991), Biochim. BIophys. Acta, 1086, 335-339.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| phosphodimethylethanolamine | competitive to phosphocholine | Rattus norvegicus |  |
| Phosphoethanolamine | competitive to phosphocholine | Rattus norvegicus | |
| phosphomonomethylethanolamine | competitive to phosphocholine | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.17 | - |
phosphocholine | pH 7, 37°C | Rattus norvegicus | |
| 4 | - |
phosphodimethylethanolamine | pH 7, 37°C | Rattus norvegicus | |
| 6.9 | - |
phosphomonomethylethanolamine | pH 7, 37°C | Rattus norvegicus | |
| 69.4 | - |
Phosphoethanolamine | pH 7, 37°C | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.35 | - |
with phosphoethanolamine as substrate | Rattus norvegicus |
| 3.45 | - |
with phosphomonomethylethanolamine as substrate | Rattus norvegicus |
| 10.7 | - |
with phosphocholine as substrate | Rattus norvegicus |
| 16.12 | - |
with phosphodimethylethanolamine as substrate | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + choline phosphate | - |
Rattus norvegicus | diphosphate + CDPcholine | - |
? | |
| CTP + ethanolamine phosphate | - |
Rattus norvegicus | diphosphate + CDPethanolamine | - |
? | |
| CTP + phosphodimethylethanolamine | - |
Rattus norvegicus | diphosphate + CDPdimethylethanolamine | - |
? | |
| CTP + phosphomonomethylethanolamine | - |
Rattus norvegicus | diphosphate + CDPmethylethanolamine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
phosphodimethylethanolamine | pH 7, 37°C | Rattus norvegicus | |
| 7.8 | - |
phosphomonomethylethanolamine | pH 7, 37°C | Rattus norvegicus | |
| 16.7 | - |
Phosphoethanolamine | pH 7, 37°C | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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