Cloned (Comment) | Organism |
---|---|
expression in Sacchaormyces cerevisiae | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D28Y | variant associated with type I galactosemia. 13.5% of wild-type activity | Homo sapiens |
F171S | variant associated with type I galactosemia, residue is strictly conserved across species. No residual activity | Homo sapiens |
F194L | variant associated with type I galactosemia. 11.9% of wild-type activity | Homo sapiens |
L74P | variant associated with type I galactosemia, residue is strictly conserved across species. No residual activity | Homo sapiens |
R333G | variant associated with type I galactosemia, residue is strictly conserved across species. 0.6% of wild.type activtiy | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-D-glucose 1-phosphate | - |
Homo sapiens | |
UDP-alpha-D-glucose | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0459 | - |
alpha-D-galactose 1-phosphate | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
0.0608 | - |
UDP-alpha-D-glucose | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
0.0816 | - |
UDP-alpha-D-glucose | wild-type, pH 8.8, 37°C | Homo sapiens | |
0.0897 | - |
UDP-alpha-D-galactose | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
0.118 | - |
alpha-D-glucose 1-phosphate | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
0.121 | - |
alpha-D-glucose 1-phosphate | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
0.141 | - |
UDP-alpha-D-galactose | wild-type, pH 8.8, 37°C | Homo sapiens | |
0.159 | - |
alpha-D-glucose 1-phosphate | wild-type, pH 8.8, 37°C | Homo sapiens | |
0.179 | - |
UDP-alpha-D-galactose | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
0.202 | - |
alpha-D-glucose 1-phosphate | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
0.2857 | - |
UDP-alpha-D-glucose | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
0.288 | - |
alpha-D-galactose 1-phosphate | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
0.29 | - |
alpha-D-galactose 1-phosphate | wild-type, pH 8.8, 37°C | Homo sapiens | |
0.324 | - |
UDP-alpha-D-galactose | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
0.4487 | - |
UDP-alpha-D-glucose | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
1.184 | - |
alpha-D-galactose 1-phosphate | mutant R333G, pH 8.8, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P07902 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose | - |
Homo sapiens | UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate | - |
r | |
UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate | - |
Homo sapiens | alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose | - |
r |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.98 | - |
UDP-alpha-D-glucose | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
2.5 | - |
UDP-alpha-D-glucose | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
5.5 | - |
alpha-D-glucose 1-phosphate | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
5.5 | - |
alpha-D-glucose 1-phosphate | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
9.3 | - |
alpha-D-glucose 1-phosphate | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
9.4 | - |
UDP-alpha-D-glucose | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
13.6 | - |
UDP-alpha-D-glucose | wild-type, pH 8.8, 37°C | Homo sapiens | |
17.7 | - |
alpha-D-glucose 1-phosphate | wild-type, pH 8.8, 37°C | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.094 | - |
UDP-alpha-D-glucose | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
0.85 | - |
UDP-alpha-D-glucose | wild-type, pH 8.8, 37°C | Homo sapiens | |
2.3 | - |
alpha-D-glucose 1-phosphate | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
3.2 | - |
alpha-D-glucose 1-phosphate | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
4.3 | - |
alpha-D-glucose 1-phosphate | wild-type, pH 8.8, 37°C | Homo sapiens | |
5.9 | - |
alpha-D-glucose 1-phosphate | mutant R333G, pH 8.8, 37°C | Homo sapiens |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.8 | - |
alpha-D-galactose 1-phosphate | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
3 | - |
UDP-alpha-D-glucose | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
16 | - |
UDP-alpha-D-galactose | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
21 | - |
UDP-alpha-D-glucose | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
27 | - |
alpha-D-glucose 1-phosphate | mutant R333G, pH 8.8, 37°C | Homo sapiens | |
33 | - |
alpha-D-galactose 1-phosphate | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
41 | - |
UDP-alpha-D-glucose | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
47 | - |
alpha-D-glucose 1-phosphate | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
47 | - |
alpha-D-galactose 1-phosphate | wild-type, pH 8.8, 37°C | Homo sapiens | |
52 | - |
UDP-alpha-D-galactose | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
54 | - |
alpha-D-galactose 1-phosphate | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
61 | - |
UDP-alpha-D-galactose | mutant F194L, pH 8.8, 37°C | Homo sapiens | |
77 | - |
alpha-D-glucose 1-phosphate | mutant D28Y, pH 8.8, 37°C | Homo sapiens | |
111 | - |
alpha-D-glucose 1-phosphate | wild-type, pH 8.8, 37°C | Homo sapiens | |
126 | - |
UDP-alpha-D-galactose | wild-type, pH 8.8, 37°C | Homo sapiens | |
167 | - |
UDP-alpha-D-glucose | wild-type, pH 8.8, 37°C | Homo sapiens |