Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.12 extracted from

  • McCorvie, T.J.; Gleason, T.J.; Fridovich-Keil, J.L.; Timson, D.J.
    Misfolding of galactose 1-phosphate uridylyltransferase can result in type I galactosemia (2013), Biochim. Biophys. Acta, 1832, 1279-1293.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sacchaormyces cerevisiae Homo sapiens

Protein Variants

Protein Variants Comment Organism
D28Y variant associated with type I galactosemia. 13.5% of wild-type activity Homo sapiens
F171S variant associated with type I galactosemia, residue is strictly conserved across species. No residual activity Homo sapiens
F194L variant associated with type I galactosemia. 11.9% of wild-type activity Homo sapiens
L74P variant associated with type I galactosemia, residue is strictly conserved across species. No residual activity Homo sapiens
R333G variant associated with type I galactosemia, residue is strictly conserved across species. 0.6% of wild.type activtiy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
alpha-D-glucose 1-phosphate
-
Homo sapiens
UDP-alpha-D-glucose
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0459
-
alpha-D-galactose 1-phosphate mutant F194L, pH 8.8, 37°C Homo sapiens
0.0608
-
UDP-alpha-D-glucose mutant F194L, pH 8.8, 37°C Homo sapiens
0.0816
-
UDP-alpha-D-glucose wild-type, pH 8.8, 37°C Homo sapiens
0.0897
-
UDP-alpha-D-galactose mutant F194L, pH 8.8, 37°C Homo sapiens
0.118
-
alpha-D-glucose 1-phosphate mutant F194L, pH 8.8, 37°C Homo sapiens
0.121
-
alpha-D-glucose 1-phosphate mutant D28Y, pH 8.8, 37°C Homo sapiens
0.141
-
UDP-alpha-D-galactose wild-type, pH 8.8, 37°C Homo sapiens
0.159
-
alpha-D-glucose 1-phosphate wild-type, pH 8.8, 37°C Homo sapiens
0.179
-
UDP-alpha-D-galactose mutant D28Y, pH 8.8, 37°C Homo sapiens
0.202
-
alpha-D-glucose 1-phosphate mutant R333G, pH 8.8, 37°C Homo sapiens
0.2857
-
UDP-alpha-D-glucose mutant R333G, pH 8.8, 37°C Homo sapiens
0.288
-
alpha-D-galactose 1-phosphate mutant D28Y, pH 8.8, 37°C Homo sapiens
0.29
-
alpha-D-galactose 1-phosphate wild-type, pH 8.8, 37°C Homo sapiens
0.324
-
UDP-alpha-D-galactose mutant R333G, pH 8.8, 37°C Homo sapiens
0.4487
-
UDP-alpha-D-glucose mutant D28Y, pH 8.8, 37°C Homo sapiens
1.184
-
alpha-D-galactose 1-phosphate mutant R333G, pH 8.8, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P07902
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
-
Homo sapiens UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate
-
r
UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate
-
Homo sapiens alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose
-
r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.98
-
UDP-alpha-D-glucose mutant R333G, pH 8.8, 37°C Homo sapiens
2.5
-
UDP-alpha-D-glucose mutant F194L, pH 8.8, 37°C Homo sapiens
5.5
-
alpha-D-glucose 1-phosphate mutant F194L, pH 8.8, 37°C Homo sapiens
5.5
-
alpha-D-glucose 1-phosphate mutant R333G, pH 8.8, 37°C Homo sapiens
9.3
-
alpha-D-glucose 1-phosphate mutant D28Y, pH 8.8, 37°C Homo sapiens
9.4
-
UDP-alpha-D-glucose mutant D28Y, pH 8.8, 37°C Homo sapiens
13.6
-
UDP-alpha-D-glucose wild-type, pH 8.8, 37°C Homo sapiens
17.7
-
alpha-D-glucose 1-phosphate wild-type, pH 8.8, 37°C Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.094
-
UDP-alpha-D-glucose mutant D28Y, pH 8.8, 37°C Homo sapiens
0.85
-
UDP-alpha-D-glucose wild-type, pH 8.8, 37°C Homo sapiens
2.3
-
alpha-D-glucose 1-phosphate mutant D28Y, pH 8.8, 37°C Homo sapiens
3.2
-
alpha-D-glucose 1-phosphate mutant F194L, pH 8.8, 37°C Homo sapiens
4.3
-
alpha-D-glucose 1-phosphate wild-type, pH 8.8, 37°C Homo sapiens
5.9
-
alpha-D-glucose 1-phosphate mutant R333G, pH 8.8, 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.8
-
alpha-D-galactose 1-phosphate mutant R333G, pH 8.8, 37°C Homo sapiens
3
-
UDP-alpha-D-glucose mutant R333G, pH 8.8, 37°C Homo sapiens
16
-
UDP-alpha-D-galactose mutant R333G, pH 8.8, 37°C Homo sapiens
21
-
UDP-alpha-D-glucose mutant D28Y, pH 8.8, 37°C Homo sapiens
27
-
alpha-D-glucose 1-phosphate mutant R333G, pH 8.8, 37°C Homo sapiens
33
-
alpha-D-galactose 1-phosphate mutant D28Y, pH 8.8, 37°C Homo sapiens
41
-
UDP-alpha-D-glucose mutant F194L, pH 8.8, 37°C Homo sapiens
47
-
alpha-D-glucose 1-phosphate mutant F194L, pH 8.8, 37°C Homo sapiens
47
-
alpha-D-galactose 1-phosphate wild-type, pH 8.8, 37°C Homo sapiens
52
-
UDP-alpha-D-galactose mutant D28Y, pH 8.8, 37°C Homo sapiens
54
-
alpha-D-galactose 1-phosphate mutant F194L, pH 8.8, 37°C Homo sapiens
61
-
UDP-alpha-D-galactose mutant F194L, pH 8.8, 37°C Homo sapiens
77
-
alpha-D-glucose 1-phosphate mutant D28Y, pH 8.8, 37°C Homo sapiens
111
-
alpha-D-glucose 1-phosphate wild-type, pH 8.8, 37°C Homo sapiens
126
-
UDP-alpha-D-galactose wild-type, pH 8.8, 37°C Homo sapiens
167
-
UDP-alpha-D-glucose wild-type, pH 8.8, 37°C Homo sapiens