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Literature summary for 2.7.7.102 extracted from
- Recent advances in understanding bacterial and archaeoeukaryotic primases (2019), Curr. Opin. Struct. Biol., 59, 159-167 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q96LW4 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PrimPol | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme plays a role in DNA damage tolerance rather than initiation of DNA replication. Because of its ability to carry out translesion synthesis and to bypass template lesions such as thymine dimers, PrimPol is important for re-priming and resolution of stalled replication forks. Physiologically, PrimPol resolves stalled replication forks that occur if DNA lesions such as UV-induced cyclobutane thymine dimers and (6-4) thymine dimers obstruct the replisome function | Homo sapiens |
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Release 2023.1 (January 2023)
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