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Literature summary for 2.7.7.102 extracted from

  • e Souza, E.; Diniz, M.
    Prediction of mutations on structure primase of the archaeon Sulfolobus solfataricus (2017), Acta Sci. Biol. Sci., 39, 463-467 .
No PubMed abstract available
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Protein Variants

Protein Variants Comment Organism
D235E mutation of aspartic acid by glutamic acid in DNA primase small (catalytic) subunit PriS may occur naturally due to a misrepair on the DNA replication and by a substitution of the third nucleotide of the codons GAU and GAC to GAA to GAG, corresponding to aspartic acid and glutamic acid, respectively. The in silico analysis suggests that these mutations in PriL may cause destabilization on its structure interfering with replication mechanisms of Saccharolobus solfataricus. In addition, the mutation may alter the interactions with other molecules, such as salt bridges Saccharolobus solfataricus
D241E mutation of aspartic acid by glutamic acid in DNA primase small (catalytic) subunit PriS may occur naturally due to a misrepair on the DNA replication and by a substitution of the third nucleotide of the codons GAU and GAC to GAA to GAG, corresponding to aspartic acid and glutamic acid, respectively. The in silico analysis suggests that these mutations in PriL may cause destabilization on its structure interfering with replication mechanisms of Saccharolobus solfataricus. In addition, the mutation may alter the interactions with other molecules, such as salt bridges Saccharolobus solfataricus
D62E mutation of aspartic acid by glutamic acid in DNA primase small (catalytic) subunit PriS may occur naturally due to a misrepair on the DNA replication and by a substitution of the third nucleotide of the codons GAU and GAC to GAA to GAG, corresponding to aspartic acid and glutamic acid, respectively. The in silico analysis suggests that these mutations in PriL may cause destabilization on its structure interfering with replication mechanisms of Saccharolobus solfataricus. In addition, the mutation may alter the interactions with other molecules, such as salt bridges Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q9UWW1 AND Q97Z83 AND Q97ZS7 Q9UWW1: DNA primase large subunit PriL, Q97Z83: DNA primase small (catalytic) subunit PriS, Q97ZS7: PriX domain-containing protein
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Saccharolobus solfataricus ATCC 35092 Q9UWW1 AND Q97Z83 AND Q97ZS7 Q9UWW1: DNA primase large subunit PriL, Q97Z83: DNA primase small (catalytic) subunit PriS, Q97ZS7: PriX domain-containing protein
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Synonyms

Synonyms Comment Organism
archaeo-eukaryotic primase
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 Saccharolobus solfataricus