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Literature summary for 2.7.7.102 extracted from

  • Garcia-Gomez, S.; Reyes, A.; Martinez-Jimenez, M.I.; Chocron, E.S.; Mouron, S.; Terrados, G.; Powell, C.; Salido, E.; Mendez, J.; Holt, I.J.; Blanco, L.
    PrimPol, an archaic primase/polymerase operating in human cells (2013), Mol. Cell, 52, 541-553 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.102

Protein Variants

Protein Variants Comment Organism
D114A/E116A mutant in two potential metal bindig sites, inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
nucleus
-
 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ presence of Mn2+ is required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96LW4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
M13 ssDNA + n dNTP
-
 Homo sapiens M13 ssDNA/pppdN(pdN)n-1 + (n-1) diphosphate
-
 ?
M13 ssDNA + n NTP
-
 Homo sapiens M13 ssDNA/pppN(pN)n-1 + (n-1) diphosphate
-
 ?
additional information a template oligonucleotide in which sequence GTCC is flanked by thymine residues is also recognized as substrate, with preferential formation of initiating dinucleotides 5'-A-dG-3' or 5'-dA-dG-3' Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
CCDC111
-
 Homo sapiens
DNA-directed primase/polymerase protein
-
 Homo sapiens
PrimPol
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function isoform PRIMPOL gene silencing or ablation impairs mitochondrial DNA replication. PrimPol is proposed to facilitate replication fork progression by acting as a translesion DNA polymerase or as a specific DNA primase reinitiating downstream of lesions that block synthesis during both mitochondrial and nuclear DNA replication Homo sapiens