Literature summary for 2.7.7.102 extracted from

Lee, J.; Park, K.; An, J.; Kang, J.; Shen, H.; Wang, J.; Eom, S.
Structural and biochemical insights into inhibition of human primase by citrate (2018), Biochem. Biophys. Res. Commun., 507, 383-388 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of small subunit Prim1 at 2.2 A resolution, with citrate in its inactive forms. Dibasic citrate is bound at the nucleotide triphosphate beta, gamma-phosphate binding site through nine hydrogen bonds. The activity of Prim1 is regulated by pH and citrate	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P49642 and P09884	P49642 i.e. small subunit Prim1, P09884, i.e. large catalytic subunit	-

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Release 2023.1 (January 2023)