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Literature summary for 2.7.7.101 extracted from

  • Benz Jr., E.; Reinberg, D.; Vicuna, R.; Hurwitz, J.
    Initiation of DNA replication by the dnaG protein (1980), J. Biol. Chem., 255, 1096-1106 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bacteriophage alpha3 ssDNA + n NTP
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Escherichia coli bacteriophage alpha3 ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate
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additional information the DnaG protein can use ADP in place of ATP. Primer formation by DnaG protein is strictly stoichiometric in vitro, one molecule of dnaG protein is required to prime one molecule of alpha3 DNA. The site recognized by DnaG protein on alpha3 DNA in vitro is within the same region of the alpha3 chromosome as the origin of replication in vivo Escherichia coli ?
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