Literature summary for 2.7.7.1 extracted from

Yue, Z.; Ma, Y.; You, J.; Li, Z.; Ding, Y.; He, P.; Lu, X.; Jiang, J.; Chen, S.; Liu, P.
NMNAT3 is involved in the protective effect of SIRT3 in Ang II-induced cardiac hypertrophy (2016), Exp. Cell Res., 347, 261-273 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q99JR6	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
acetylation	SIRT3 increases NMNAT3 activity by interacting with and deacetylating NMNAT3	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac muscle fiber	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
nicotinamide mononucleotide adenylyltransferase	-	Mus musculus
NMNAT3	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	NMNAT3 is a target and binding partner of sirtuin SIRT3. SIRT3 physically interacts with and deacetylates NMNAT3, thereby enhancing the enzyme activity of NMNAT3 and contributing to SIRT3-mediated anti-hypertrophic effects. NMNAT3 regulates the activity of SIRT3 via synthesis of mitochondrial NAD+	Mus musculus

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Release 2023.1 (January 2023)